CAS 13292-22-3
:3-Formylrifamycin
Description:
3-Formylrifamycin is a chemical compound belonging to the rifamycin class of antibiotics, which are derived from the bacterium Amycolatopsis rifamycinica. This substance is characterized by its complex structure, featuring a naphthalenic core with various functional groups, including an aldehyde group at the 3-position. It exhibits potent antibacterial activity, particularly against Mycobacterium tuberculosis, making it significant in the treatment of tuberculosis and other bacterial infections. The compound's mechanism of action involves inhibiting bacterial RNA synthesis by binding to the DNA-dependent RNA polymerase, thereby preventing transcription. Additionally, 3-Formylrifamycin may possess unique pharmacokinetic properties, influencing its absorption, distribution, metabolism, and excretion in biological systems. Its chemical stability and solubility can vary based on environmental conditions, which are crucial for its therapeutic efficacy. As with many antibiotics, resistance can develop, necessitating ongoing research into its use and potential modifications to enhance its effectiveness against resistant strains.
Formula:C38H47NO13
InChI:InChI=1/C38H47NO13/c1-16-11-10-12-17(2)37(48)39-28-23(15-40)32(45)25-26(33(28)46)31(44)21(6)35-27(25)36(47)38(8,52-35)50-14-13-24(49-9)18(3)34(51-22(7)41)20(5)30(43)19(4)29(16)42/h10-16,18-20,24,29-30,34,42-46H,1-9H3,(H,39,48)/b11-10+,14-13+,17-12+/t16-,18+,19+,20+,24-,29-,30+,34+,38-/m0/s1
InChI key:InChIKey=BBNQHOMJRFAQBN-UPZFVJMDSA-N
SMILES:O=C1C=2C=3C4=C(O)C(=C(C=O)C3O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O
Synonyms:- (2S,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
- 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-8-carboxaldehyde, 1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-, 21-acetate
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
- 3-Formylrifampicin SV
- 3-Formylrifamycin
- 3-Formylrifamycin SV
- Nci 145-635
- Rifaldehyde
- Rifamycin AF
- Rifamycin, 3-formyl-
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Found 11 products.
3-Formyl Rifamycin
CAS:Applications A metabolite of Rifampicin, a Rifamycin antibiotic.
References Assandri, A., et al.: J. Antibiot., 37, 1066 (1984), Utkin, I., et al.: Drug. Metab. Dispos., 25, 963 (1997), Weber, A., et al.: Biopharm. Drug. Dispos., 22(4), 157 (2001), Marek, C., et al.: Biochem. J., 387, 601 (2005),Formula:C38H47NO13Color and Shape:Dark RedMolecular weight:725.783-Formyl rifamycin
CAS:3-Formyl rifamycin is a degradation product of Rifampicin, with antibacterial activity.Formula:C38H47NO13Purity:97.69%Color and Shape:SolidMolecular weight:725.783-Formyl rifamycin
CAS:3-Formyl rifamycin is an intermediate in the synthesis of rifampicin that has been used to develop rifamycin derivatives with antibiotic activity. Rifampicin is aa anti-tuberculosis drug that inhibits bacterial DNA replicationFormula:C38H47NO13Purity:Min. 99 Area-%Color and Shape:Red PowderMolecular weight:725.78 g/mol
