CAS 13292-46-1

rifampicin

Description:

Rifampicin, with the CAS number 13292-46-1, is a semi-synthetic antibiotic belonging to the rifamycin class. It is primarily used to treat bacterial infections, particularly tuberculosis and leprosy, by inhibiting bacterial RNA synthesis. The compound exhibits a reddish-orange color and is known for its lipophilic nature, allowing it to penetrate cell membranes effectively. Rifampicin has a relatively low solubility in water but is soluble in organic solvents such as ethanol and acetone. Its mechanism of action involves binding to the beta-subunit of bacterial RNA polymerase, thereby preventing the transcription of DNA into RNA. This antibiotic is often administered in combination with other drugs to prevent the development of resistance. Additionally, rifampicin is metabolized in the liver and can induce cytochrome P450 enzymes, affecting the metabolism of other medications. Due to its potent effects and potential side effects, including hepatotoxicity and interactions with other drugs, careful monitoring is essential during treatment.

Formula: C₄₃H₅₈N₄O₁₂

InChI: InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20?/t21?,23-,24-,25-,29+,34+,35-,39+,43+/m1/s1

InChI key: InChIKey=JQXXHWHPUNPDRT-ZNQWNCHJSA-N

SMILES: OC1=C2C3=C4O[C@@](C)(C3=O)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)NC(C(O)=C2C(O)=C4C)=C1C=NN5CCN(C)CC5

Synonyms:

• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate
• 3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
• 3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
• 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)-naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
• Abrifam
• Ba 41166/E
• Dipicin
• Eremfat
• Famcin
• L 5103 Lepetit
• Nih 10782
• Nsc 113926
• R-Cin
• R/Amp
• RIF
• Refampicin
• Rifa
• Rifacap
• Rifactine
• Rifadin
• Rifadin I.V.
• Rifadine
• Rifaldazine
• Rifaldin
• Rifamate
• Rifamicin AMP
• Rifampicin SV
• Rifampicina
• Rifampicine
• Rifampin
• Rifamycin AMP
• Rifamycin SV Sodium
• Rifamycin, 3-[[(4-methyl-1-piperazinyl)imino]methyl]-
• Rifamyzin 3-(4-Methyl-Piperazinyl)Iminomethyl
• Rifandin
• Rifaprodin
• Rifater
• Rifobac
• Rifodex
• Rifoldin
• Rifoldine
• Riforal
• Rimactan
• Rimactane
• Rimapen
• Rimycin
• Sinerdol

Rifampicin

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Purity: >98.0%(T)

Color and Shape: Orange to Amber to Dark red powder to crystal

Molecular weight: 822.95

Ref: 3B-R0079

Rifampin, Molecular Biology Reagent

CAS: 13292-46-1

Rifampin, 13292-46-1, also known as rifampicin, is a synthetic rifamycin antibiotic that works by inhibiting RNA and DNA synthesis. Learn more at Thermo Fisher Scientific.

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Red-brown, Crystals or powder or crystalline powder

Molecular weight: 822.95

Ref: 02-J60836

Rifampicin

CAS: 13292-46-1

Color and Shape: Dark Red

Ref: 61-FOR0514.00

RIFAMPICIN CRS

CAS: 13292-46-1

RIFAMPICIN CRS

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Crystalline Powder. Dark Red. Brown. Powder.

Molecular weight: 822.9402

Ref: 41-R0700000

Rifampin

CAS: 13292-46-1

Antibiotics nesoi

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Reddish-Brown Powder

Molecular weight: 822.40512

Ref: 45-1604009

Rifampicin

CAS: 13292-46-1

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic with strong antibacterial effect against Mycobacterium tuberculosis. Cost effective and quality assured.

Formula: C₄₃H₅₈N₄O₁₂

Purity: 96.7% - 98.52%

Color and Shape: Red To Orange Platelets From Acetone Solid

Molecular weight: 822.94

Ref: TM-T0681

3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 822.9402

Ref: IN-DA00397J

Rifampicin

CAS: 13292-46-1

Rifampicin

Purity: ≥95%

Molecular weight: 822.94g/mol

Ref: 54-BUP18382

Rifampicin

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Purity: 97.0 - 102.0 % (dried basis)

Color and Shape: Red to brown crystalline powder

Molecular weight: 822.94

Ref: 7W-GA1853

Rifampicin

CAS: 13292-46-1

Rifampicin

Formula: C₄₃H₅₈N₄O₁₂

Purity: 95%

Color and Shape: dark red powder

Molecular weight: 822.94022g/mol

Ref: 54-BIR0146

Rifampicin

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Orange Red Solid

Molecular weight: 822.95

Ref: 4Z-R-234

Rifampicin-d4

CAS: 13292-46-1

Formula: C₄₃H₅₄D₄N₄O₁₂

Color and Shape: Dark Orange Solid

Molecular weight: 826.98

Ref: 4Z-R-236

Rifampicin-d11 (4-methyl-d3-1-piperazinyl-d8)

CAS: 13292-46-1

Purity: 98 atom % D

Molecular weight: 833.97

Ref: 3U-D8131

Rifampicin

Controlled Product

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Neat

Molecular weight: 822.94

Ref: 86-MM0514.00

Rifampicin

Controlled Product

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Neat

Molecular weight: 822.94

Ref: 04-C16814500

Rifampicin-13C-d3

CAS: 13292-46-1

Formula: C₄₃H₅₅N₄O₁₂D₃

Molecular weight: 826.97

Ref: 4Z-R-235

Rifampicin

Controlled Product

CAS: 13292-46-1

Applications Semisynthetic antibiotic. Antibacerial (tuberculostatic).
References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),

Formula: C₄₃H₅₈N₄O₁₂

Color and Shape: Dark Red

Molecular weight: 822.94

Ref: TR-R508000

Rifampicin

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Molecular weight: 822.95

Ref: ST-EA-CP-R33000

Rifampicin-d4

Controlled Product

CAS: 13292-46-1

Formula: C₄₃D₄H₅₄N₄O₁₂

Color and Shape: Neat

Molecular weight: 826.965

Ref: TR-R508043

Rifampicin-d8

Controlled Product

CAS: 13292-46-1

Formula: C₄₃D₈H₅₀N₄O₁₂

Color and Shape: Neat

Molecular weight: 830.99

Ref: TR-R508003

Rifampicin

CAS: 13292-46-1

Inhibitor of RNA synthesis

Formula: C₄₃H₅₈N₄O₁₂

Purity: Min. 95%

Color and Shape: Orange Red Powder

Molecular weight: 822.94 g/mol

Ref: 3D-AR11351

Rifampicin (RFP) (Rifampin), 97-102%

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Purity: 97-102%

Color and Shape: A brick red to reddish brown, Crystalline powder

Molecular weight: 822.95

Ref: SR-12310

Rifampicin (RFP) (Rifampin) for cell culture, 97-102%, Endotoxin (BET) 0.05EU/mg

CAS: 13292-46-1

Formula: C₄₃H₅₈N₄O₁₂

Purity: 97-102%

Color and Shape: A brick red to reddish brown, Crystalline powder

Molecular weight: 822.95

Ref: SR-46143

Rifampicin, Antibiotic for Culture Media Use Only

CAS: 13292-46-1

Rifampicin is a drug that inhibits protein synthesis in bacteria and is used to treat tuberculosis. Rifampicin binds to the beta subunit of the bacterial RNA polymerase, inhibiting transcription and translation. It has been shown to inhibit the acetylcholine receptor function in rats, which may be related to its antituberculosis activity. Histopathological studies have shown that rifampicin inhibits the growth of human tumors in mice, including lung cancer, breast cancer, and leukemia. The drug is also being studied for its potential use in treating Alzheimer's disease. The pharmacokinetics and oral bioavailability of rifampicin have been studied and Rifampicin has been shown to be an effective anti-tuberculosis drug.

Formula: C₄₃H₅₈N₄O₁₂

Purity: Min. 90.0 Area-%

Molecular weight: 822.94 g/mol

Ref: 3D-R-6000

RIFAMPICIN RS

CAS: 13292-46-1

RIFAMPICIN RS

Formula: C₄₃H₅₈N₄O₁₂

Molecular weight: 822.9402

Ref: 41-ICRS0409