N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine hydrochloride is a chemical compound characterized by its complex structure, which includes a benzyl group, a chloroethyl moiety, and a phenoxy group that is heavily deuterated. The presence of deuterium atoms in the phenoxy group can influence the compound's physical and chemical properties, such as its stability and reactivity. As a hydrochloride salt, it is typically more soluble in water compared to its free base form, which can enhance its bioavailability in pharmaceutical applications. This compound may exhibit specific pharmacological activities due to its amine functionality, which is often associated with neurotransmitter interactions. Its unique structure suggests potential applications in medicinal chemistry, particularly in the development of drugs targeting the central nervous system. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its potential uses and safety profile.

Phenoxybenzamine-d
5
is intended for use as an internal standard for the quantification of phenoxybenzamine by GC- or LC-MS. Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs). It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α
1
-ARs (EC
50
s = 125.9-316.2 nM), as well as radioligand binding to α
2A
-, α
2B
-, and α
2C
-ARs in CHO cell membranes (K
i
s = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 μM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips. It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC
50
values ranging from 29.5 to 99.8 μM. Phenoxybenzamine (3-1,000 μg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline , St-587, Sgd 101/75, and B-HT 920 in pithed rats. It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI). Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.

N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine:hydrochloride

1329838-45-0: N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine hydrochloride is a chemical compound characterized by its complex structure, which includes a benzyl group, a chloroethyl moiety, and a phenoxy group that is heavily deuterated. The presence of deuterium atoms in the phenoxy group can influence the compound's physical and chemical properties, such as its stability and reactivity. As a hydrochloride salt, it is typically more soluble in water compared to its free base form, which can enhance its bioavailability in pharmaceutical applications. This compound may exhibit specific pharmacological activities due to its amine functionality, which is often associated with neurotransmitter interactions. Its unique structure suggests potential applications in medicinal chemistry, particularly in the development of drugs targeting the central nervous system. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its potential uses and safety profile.

CAS 1329838-45-0

N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine:hydrochloride

Phenoxybenzamine-d5 HCl

Ref: 4Z-P-081

Phenoxybenzamine-d5 Hydrochloride

Ref: TR-P227992