Chloroprocaine is a local anesthetic belonging to the ester class of anesthetics, primarily used for its rapid onset and short duration of action. It is characterized by its ability to block nerve conduction, making it effective for various medical procedures, particularly in regional anesthesia. The chemical structure of chloroprocaine includes a p-aminobenzoic acid derivative, which contributes to its anesthetic properties. It is typically administered via injection and is known for its relatively low toxicity compared to other local anesthetics. Chloroprocaine is often favored in outpatient settings due to its quick recovery profile, allowing patients to regain sensation and mobility shortly after administration. However, it may cause side effects such as allergic reactions or transient neurological symptoms in some individuals. Its use is contraindicated in patients with known hypersensitivity to ester-type anesthetics. Overall, chloroprocaine is a valuable tool in clinical practice for providing localized pain relief during surgical and diagnostic procedures.

Chloroprocaine (N,N′-diethylaminoethyl 4-amino-2-chlorobenzoate) is a very short-acting, amino
ester-type local anesthetic used to provide regional anesthesia by infiltration as well as by
peripheral and central nerve block, including lumbar and caudal epidural blocks. The presence of
a chlorine atom ortho to the carbonyl of the ester function increases its rate of hydrolysis by
plasma cholinesterase at least threefold compared to procaine and benzocaine. Thus,
chloroprocaine may be used in maternal and neonatal patients with minimal placental passage of
chloroprocaine. The lower plasma cholinesterase activity in the maternal epidural space must still
have sufficient activity for degrading chloroprocaine and, thus, not allowing it to cross the
placenta barrier. Like PABA, the hydrolysis product of chloroprocaine, 4-amino-2-chlorobenzoic acid, also inhibits
the action of sulfonamides. Therefore, its use with sulfonamides should be avoided.

Chloroprocaine

133-16-4: Chloroprocaine is a local anesthetic belonging to the ester class of anesthetics, primarily used for its rapid onset and short duration of action. It is characterized by its ability to block nerve conduction, making it effective for various medical procedures, particularly in regional anesthesia. The chemical structure of chloroprocaine includes a p-aminobenzoic acid derivative, which contributes to its anesthetic properties. It is typically administered via injection and is known for its relatively low toxicity compared to other local anesthetics. Chloroprocaine is often favored in outpatient settings due to its quick recovery profile, allowing patients to regain sensation and mobility shortly after administration. However, it may cause side effects such as allergic reactions or transient neurological symptoms in some individuals. Its use is contraindicated in patients with known hypersensitivity to ester-type anesthetics. Overall, chloroprocaine is a valuable tool in clinical practice for providing localized pain relief during surgical and diagnostic procedures.

CAS 133-16-4

Chloroprocaine

Chloroprocaine

Ref: TM-T60469