CAS 133040-01-4

Eprosartan

Description:

Eprosartan is an antihypertensive medication classified as an angiotensin II receptor blocker (ARB). It is primarily used to treat high blood pressure and is known for its ability to relax blood vessels, thereby reducing blood pressure and improving blood flow. The chemical formula of eprosartan is C20H24N2O4S, and it features a sulfonamide group, which contributes to its pharmacological activity. Eprosartan is characterized by its relatively high solubility in water and moderate lipophilicity, allowing for effective absorption in the gastrointestinal tract. The compound has a specific stereochemistry that is crucial for its interaction with the angiotensin II receptor. Eprosartan is typically administered orally and is often well-tolerated, with a side effect profile that may include dizziness, fatigue, and gastrointestinal disturbances. Its mechanism of action involves blocking the effects of angiotensin II, a peptide that constricts blood vessels, thus playing a significant role in the regulation of blood pressure. Overall, eprosartan is an important therapeutic agent in the management of hypertension.

Formula: C₂₃H₂₄N₂O₄S

InChI: InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+

InChI key: InChIKey=OROAFUQRIXKEMV-LDADJPATSA-N

SMILES: C(N1C(/C=C(\CC2=CC=CS2)/C(O)=O)=CN=C1CCCC)C3=CC=C(C(O)=O)C=C3

Synonyms:

• ((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid
• (E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid
• (E)-2-Butyl-1-(p-carboxybenzyl)-α-2-thenylimidazole-5-acrylic acid
• (E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid
• (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid
• 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-
• 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-
• 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid
• 4-({2-butyl-5-[2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid
• Eporlosartan
• Eprosartan Mysylate
• Navixen
• Skb 108566
• Skf-108566)
• Skf-108566J

Eprosartan Mesylate

CAS: 133040-01-4, 144143-96-4

Formula: C₂₃H₂₄N₂O₄S·CH₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 520.62

Ref: 3B-E1161

2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-

CAS: 133040-01-4

Formula: C₂₃H₂₄N₂O₄S

Purity: 95%

Color and Shape: Solid

Molecular weight: 424.5127

Ref: IN-DA0011JO

Eprosartan

CAS: 133040-01-4

Eprosartan

Purity: ≥98%

Molecular weight: 424.51g/mol

Ref: 54-BUP06363

Eprosartan

CAS: 133040-01-4

Formula: C₂₃H₂₄N₂O₄S

Molecular weight: 424.51

Ref: 7W-GP1035

Eprosartan

CAS: 133040-01-4

Eprosartan is a selective AT1 receptor blocker with IC50s of 9.2 nM (rat) and 3.9 nM (human), used for hypertension.

Formula: C₂₃H₂₄N₂O₄S

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 424.51

Ref: TM-T2531L

Eprosartan-d4

CAS: 133040-01-4

Formula: C₂₃H₂₀N₂O₄SD₄

Color and Shape: White To Off-White Solid

Molecular weight: 428.55

Ref: 4Z-E-152

Eprosartan

Controlled Product

CAS: 133040-01-4

Formula: C₂₃H₂₄N₂O₄S

Color and Shape: Neat

Molecular weight: 424.51

Ref: TR-E590100

Eprosartan

CAS: 133040-01-4

Eprosartan is a drug which is an angiotensin II receptor antagonist (ARB). It blocks the binding of angiotensin II to its receptors and inhibits the action of this hormone on blood vessels, kidneys and heart. Eprosartan also has vasodilating effects. Eprosartan has been shown to be effective in lowering blood pressure and preventing congestive heart failure in experimental models. This drug has been shown to have no significant effect on cardiac function or blood pressure when taken with losartan, a drug that also blocks the angiotensin II receptor.

Formula: C₂₃H₂₄N₂O₄S

Purity: Min. 95%

Molecular weight: 424.51 g/mol

Ref: 3D-FE22770