CAS 133046-47-6

2-(Trifluoromethyl)-4-thiazolemethanol

Description:

2-(Trifluoromethyl)-4-thiazolemethanol is a chemical compound characterized by its thiazole ring, which is a five-membered heterocyclic structure containing both sulfur and nitrogen. The presence of a trifluoromethyl group (-CF3) significantly influences its chemical properties, enhancing its lipophilicity and potentially its biological activity. This compound typically exhibits a colorless to pale yellow appearance and is soluble in organic solvents. Its thiazole moiety can participate in various chemical reactions, making it a versatile intermediate in organic synthesis. The hydroxymethyl group (-CH2OH) contributes to its reactivity, allowing for potential interactions in biological systems. Due to the trifluoromethyl group, the compound may exhibit unique electronic properties, which can affect its reactivity and stability. Overall, 2-(Trifluoromethyl)-4-thiazolemethanol is of interest in medicinal chemistry and material science, where its unique structural features may lead to the development of novel pharmaceuticals or agrochemicals.

Formula: C₅H₄F₃NOS

InChI: InChI=1S/C5H4F3NOS/c6-5(7,8)4-9-3(1-10)2-11-4/h2,10H,1H2

InChI key: InChIKey=NGTOSARTLLCFTQ-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=NC(CO)=CS1

Synonyms:

• (2-(Trifluoromethyl)thiazol-4-yl)methanol
• 2-(Trifluoromethyl)-4-thiazolemethanol
• [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol
• 4-Thiazolemethanol, 2-(trifluoromethyl)-

(2-(Trifluoromethyl)thiazol-4-yl)methanol

CAS: 133046-47-6

Formula: C₅H₄F₃NOS

Molecular weight: 183.1516

Ref: IN-DA0011KD

4-(Hydroxymethyl)-2-(trifluoromethyl)-1,3-thiazole

CAS: 133046-47-6

4-(Hydroxymethyl)-2-(trifluoromethyl)-1,3-thiazole

Purity: ≥95%

Molecular weight: 183.15g/mol

Ref: 54-PC48416

(2-(Trifluoromethyl)thiazol-4-yl)methanol

CAS: 133046-47-6

(2-(Trifluoromethyl)thiazol-4-yl)methanol is a benzimidazole derivative that inhibits the activity of imidazopyridine N-acetyltransferase, which is an enzyme involved in the synthesis of histamine. It has shown to be selective for this enzyme and not affect other enzymes related to histamine synthesis. (2-(Trifluoromethyl)thiazol-4-yl)methanol does not show mutagenicity or genotoxicity in f344 rats and has a low safety profile when tested on humans. This drug has been shown to have antiobesity effects, which are likely due to its inhibition of histamine synthesis.

Formula: C₅H₄F₃NOS

Purity: Min. 95%

Molecular weight: 183.15 g/mol

Ref: 3D-IFA04647