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CAS 133180-01-5

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Fmoc-Thr(Trt)-OH

Description:
Fmoc-Thr(Trt)-OH, with the CAS number 133180-01-5, is a protected amino acid derivative commonly used in peptide synthesis. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The "Thr" indicates that the amino acid is threonine, which contains a hydroxyl group in its side chain, contributing to its hydrophilicity and potential for hydrogen bonding. The "Trt" (trityl) group protects the hydroxyl side chain of threonine, enhancing stability and preventing unwanted reactions during synthesis. This compound is typically utilized in solid-phase peptide synthesis, where the protection of functional groups is crucial for the stepwise addition of amino acids. Fmoc-Thr(Trt)-OH is characterized by its ability to undergo deprotection under mild basic conditions, allowing for the release of the free threonine residue when needed. Its structural features and protective groups make it a valuable building block in the design of peptides and other bioactive compounds.
Formula:C38H33NO5
InChI:InChI=1/C38H33NO5/c1-26(44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29)35(36(40)41)39-37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34/h2-24,26,34-35H,25H2,1H3,(H,39,42)(H,40,41)/t26-,35+/m1/s1
Synonyms:
  • N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-threonine
  • N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-L-threonine
  • Fmoc-O-Trityl-L-Threonine
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