CAS 133242-30-5: Landiolol

Description: Landiolol is a selective beta-1 adrenergic antagonist, primarily used in clinical settings for its rapid onset and short duration of action, making it suitable for managing acute situations such as tachycardia and hypertension. It is characterized by its ability to selectively inhibit beta-1 receptors in the heart, leading to decreased heart rate and myocardial contractility without significantly affecting beta-2 receptors, which are involved in bronchial dilation. This selectivity is particularly beneficial for patients with respiratory issues, as it minimizes potential bronchoconstriction. Landiolol is typically administered intravenously due to its pharmacokinetic profile, which allows for quick adjustments in dosage to achieve the desired therapeutic effect. Its chemical structure includes a chiral center, contributing to its pharmacological properties. The substance is generally well-tolerated, with a side effect profile similar to other beta-blockers, including potential bradycardia and hypotension. Overall, Landiolol represents a valuable option in the management of cardiovascular conditions, particularly in acute care settings.

Formula: C₂₅H₃₉N₃O₈

InChI: InChI=1S/C25H39N3O8/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31)/t20-,22+/m0/s1

InChI key: InChIKey=WMDSZGFJQKSLLH-RBBKRZOGSA-N

SMILES: O=C(OCC1OC(OC1)(C)C)CCC2=CC=C(OCC(O)CNCCNC(=O)N3CCOCC3)C=C2

Synonyms:

• Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester
• Benzenepropanoic acid, 4-[2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester, [S-(R*,R*)]-
• Ono 1101
• [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate
• [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)propanoate
• methyl (3ξ)-2,3-dideoxy-3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)-4,5-O-(1-methylethylidene)-D-glycero-pentonate hydrochloride (1:1)
• Landiolol

Landiolol-d8

CAS: 133242-30-5

• Formula: C₂₅H₃₁D₈N₃O₈
• Molecular weight: 517.65

Landiolol

CAS: 133242-30-5

• Formula: C₂₅H₃₉N₃O₈
• Molecular weight: 509.60

Landiolol Hydrochloride

CAS: 133242-30-5144481-98-1

• Formula: C₂₅H₃₉N₃O₈·HCl
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 546.06

Landiolol-D4

CAS: 133242-30-5

• Formula: C₂₅D₄H₃₅N₃O₈
• Color and Shape: Neat
• Molecular weight: 513.617

Landiolol

CAS: 133242-30-5

Landiolol is used as a highly cardioselective ultra short-acting beta-blocker.

• Formula: C₂₅H₃₉N₃O₈
• Purity: 98%
• Color and Shape: White Crystalline Powder
• Molecular weight: 509.59

Landiolol-d4

CAS: 133242-30-5

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• Formula: C₂₅H₃₉N₃O₈
• Purity: Min. 95%
• Molecular weight: 509.6 g/mol