CAS 133242-30-5

Landiolol

Description:

Landiolol is a selective beta-1 adrenergic antagonist, primarily used in clinical settings for its rapid onset and short duration of action, making it suitable for managing acute situations such as tachycardia and hypertension. It is characterized by its ability to selectively inhibit beta-1 receptors in the heart, leading to decreased heart rate and myocardial contractility without significantly affecting beta-2 receptors, which are involved in bronchial dilation. This selectivity is particularly beneficial for patients with respiratory issues, as it minimizes potential bronchoconstriction. Landiolol is typically administered intravenously due to its pharmacokinetic profile, which allows for quick adjustments in dosage to achieve the desired therapeutic effect. Its chemical structure includes a chiral center, contributing to its pharmacological properties. The substance is generally well-tolerated, with a side effect profile similar to other beta-blockers, including potential bradycardia and hypotension. Overall, Landiolol represents a valuable option in the management of cardiovascular conditions, particularly in acute care settings.

Formula: C₂₅H₃₉N₃O₈

InChI: InChI=1S/C25H39N3O8/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31)/t20-,22+/m0/s1

InChI key: InChIKey=WMDSZGFJQKSLLH-RBBKRZOGSA-N

SMILES: C(CC(OC[C@H]1OC(C)(C)OC1)=O)C2=CC=C(OC[C@H](CNCCNC(=O)N3CCOCC3)O)C=C2

Synonyms:

• Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester
• Benzenepropanoic acid, 4-[2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester, [S-(R*,R*)]-
• Ono 1101
• [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate
• [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)propanoate
• methyl (3ξ)-2,3-dideoxy-3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)-4,5-O-(1-methylethylidene)-D-glycero-pentonate hydrochloride (1:1)
• Landiolol
• (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-hydroxy-3-(2-morpholino-carbonylamino)ethylamino]propoxy]phenylpropionate monohydrochloride
• ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate
• Landiolol HCL EP USP
• Landiolol USP/EP/BP
• ((–)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(S)-2-hydroxy-3-(2-morpholino-carbonylamino)ethylamino] propoxy}phenylpropionate)

Landiolol-d8

CAS: 133242-30-5

Formula: C₂₅H₃₁D₈N₃O₈

Molecular weight: 517.65

Ref: 4Z-L-100035

Landiolol

CAS: 133242-30-5

Formula: C₂₅H₃₉N₃O₈

Molecular weight: 509.60

Ref: 4Z-L-100001

Landiolol-D4

Controlled Product

CAS: 133242-30-5

Formula: C₂₅D₄H₃₅N₃O₈

Color and Shape: Neat

Molecular weight: 513.617

Ref: TR-L173902

Landiolol

CAS: 133242-30-5

Landiolol is used as a highly cardioselective ultra short-acting beta-blocker.

Formula: C₂₅H₃₉N₃O₈

Purity: 98%

Color and Shape: White Crystalline Powder

Molecular weight: 509.59

Ref: TM-T5028L

Landiolol Hydrochloride

CAS: 133242-30-5, 144481-98-1

Formula: C₂₅H₃₉N₃O₈·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 546.06

Ref: 3B-L0296