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CAS 133268-58-3

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18-Hydroxyeicosatetraenoic acid

Description:
18-Hydroxyeicosatetraenoic acid (18-HETE) is a bioactive lipid derived from arachidonic acid, characterized by its hydroxylation at the 18th carbon position. It is part of the eicosanoid family, which plays crucial roles in various physiological processes, including inflammation, vascular function, and cell signaling. 18-HETE is primarily produced in the body through the action of lipoxygenases and cytochrome P450 enzymes. This compound exhibits a range of biological activities, such as promoting vasoconstriction and influencing platelet aggregation, making it significant in cardiovascular health. Additionally, 18-HETE has been implicated in the regulation of renal function and the modulation of inflammatory responses. Its presence in various tissues highlights its importance in both normal physiology and pathological conditions. As a research subject, 18-HETE is of interest for its potential therapeutic applications, particularly in the context of cardiovascular diseases and inflammatory disorders. Understanding its mechanisms of action and interactions with other signaling molecules continues to be an area of active investigation in biomedical research.
Formula:C20H32O3
InChI:InChI=1/C20H32O3/c1-2-19(21)17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-20(22)23/h4-7,10-13,19,21H,2-3,8-9,14-18H2,1H3,(H,22,23)/b6-4-,7-5-,12-10-,13-11-
InChI key:InChIKey=PPCHNRUZQWLEMF-XBOCNYGYNA-N
SMILES:C(CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)(CC)O
Synonyms:
  • (5Z,8Z,11Z,14Z)-18-Hydroxy-5,8,11,14-eicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-18-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 18-Hete
  • 18-Hydroxyarachidonic acid
  • 18-Hydroxyeicosatetraenoic acid
  • 5,8,11,14-Eicosatetraenoic acid, 18-hydroxy-, (5Z,8Z,11Z,14Z)-
  • 5,8,11,14-Eicosatetraenoic acid, 18-hydroxy-, (all-Z)-
  • rac-(5Z,8Z,11Z,14Z)-18-hydroxyeicosa-5,8,11,14-tetraenoic acid
  • 18 hydroxy arachidonic acid
  • 18-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • PPCHNRUZQWLEMF-XBOCNYGYSA-N
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