CAS 133330-60-6

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity)

Description:

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one, commonly referred to as Loratadine Impurity, is a chemical compound that belongs to the class of heterocyclic organic compounds. It features a complex bicyclic structure that includes both a benzene and a pyridine ring, contributing to its unique chemical properties. The presence of dichloro substituents indicates that chlorine atoms are attached to the carbon framework, which can influence the compound's reactivity and stability. This impurity is often studied in the context of pharmaceutical chemistry, particularly in relation to the synthesis and quality control of Loratadine, an antihistamine used to treat allergies. The compound's molecular structure suggests potential interactions with biological systems, although its specific biological activity may vary. Understanding the characteristics of such impurities is crucial for ensuring the safety and efficacy of pharmaceutical products. As with many organic compounds, it is important to handle this substance with care, adhering to safety protocols due to its chemical nature.

Formula: C₁₄H₉Cl₂NO

InChI: InChI=1/C14H9Cl2NO/c15-9-2-4-10-8(7-9)1-3-11-12(16)5-6-17-13(11)14(10)18/h2,4-7H,1,3H2

SMILES: C1Cc2c(ccnc2C(=O)c2ccc(cc12)Cl)Cl

Synonyms:

• Loratadine Impurity
• 4,8-dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
• 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(Loratadine Impurity)
• Loratadine USP RC E
• Loratadine USP Related CoMpound E
• 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 4,8-dichloro-5,6-dihydro-

Loratadine USP Related Compound E

CAS: 133330-60-6

Formula: C₁₄H₉Cl₂NO

Molecular weight: 278.13

Ref: ST-EA-CP-L5021

Loratadine Impurity E

CAS: 133330-60-6

Formula: C₁₄H₉Cl₂NO

Color and Shape: Solid

Molecular weight: 278.1334

Ref: IN-DA0014NQ

Loratadine Impurity 24

CAS: 133330-60-6

Formula: C₁₄H₉Cl₂NO

Color and Shape: White To Off-White Solid

Molecular weight: 278.13

Ref: 4Z-L-1024

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine Impurity)

Controlled Product

CAS: 133330-60-6

Impurity Loratadine USP Related Compound E
Applications Loratadine impurity. Loratidine impurity E. Loratadine USP Related Compound E.
References Villani, et al.: J. Med. Chem., 15, 750 (1972), Zhong, D., et al.: Pharmazie, 49, 736 (1994), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),

Formula: C₁₄H₉Cl₂NO

Color and Shape: Neat

Molecular weight: 278.13

Ref: TR-D434160

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

CAS: 133330-60-6

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a drug that has been developed for the treatment of cancer. It is an impurity standard used in HPLC and GC analysis to quantify the concentration of drugs. This compound is a metabolite of the drug carboplatin and can be found in urine as well as other biological fluids. Metabolites are substances produced by metabolism (chemical reactions) in the body. 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one can also be found naturally in plants such as ivy or wild parsnip.

Formula: C₁₄H₉Cl₂NO

Purity: Min. 95%

Molecular weight: 278.13 g/mol

Ref: 3D-ID21639