CAS 133407-82-6

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Description:

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide, with the CAS number 133407-82-6, is a synthetic compound that belongs to the class of peptides and peptide derivatives. This substance features a complex structure characterized by the presence of two leucine amino acid residues, which contribute to its hydrophobic properties and potential biological activity. The phenylmethoxycarbonyl group enhances its stability and solubility, while the formyl-3-methylbutyl moiety may influence its interaction with biological targets. The compound is likely to exhibit specific conformational characteristics due to the presence of chiral centers, which can affect its pharmacological properties. As a peptide derivative, it may have applications in medicinal chemistry, particularly in the development of therapeutics targeting specific biological pathways. Its synthesis and characterization would typically involve standard peptide coupling techniques, and its activity could be assessed through various biochemical assays. Overall, this compound represents a fascinating area of study within peptide chemistry and drug design.

Formula: C₂₆H₄₁N₃O₅

InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key: InChIKey=TZYWCYJVHRLUCT-VABKMULXSA-N

SMILES: [C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@@H](CC(C)C)C=O)=O)CC(C)C

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-
• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-
• Calpain Inhibitor IV
• Calpain inhibitor IV-2
• Mg-132
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-<smallcap>L</span>-leucinamide
• N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide
• N-[(benzyloxy)carbonyl]leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]leucinamide
• Z-Leu-Leu-Leu-aldehyde
• N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
• L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(1-formyl-3-methylbutyl)-, (S)-

MG-132

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purity: >95.0%(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 475.63

Ref: 3B-M3244

MG 132

CAS: 133407-82-6

Inhibitor of calpain proteases

Formula: C₂₆H₄₁N₃O₅

Color and Shape: Crystalline solid

Molecular weight: 475.63

Ref: 02-J63250

MG 132

CAS: 133407-82-6

Z-LLL-CHO (MG132) was shown to initiate neurite outgrowth in PC12 cells with an optimal concentration of 20 nM and to be a very strong inhibitor of 20S proteasome and of calpain.

Formula: C₂₆H₄₁N₃O₅

Purity: 92.5%

Color and Shape: White

Molecular weight: 475.63

Ref: 01-4027888

L-​Leucinamide, N-​[(phenylmethoxy)​carbonyl]​-​L-​leucyl-​N-​[(1S)​-​1-​formyl-​3-​methylbutyl]​-

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 475.6208

Ref: IN-DA0072SK

Calpain inhibitor IV

CAS: 133407-82-6

Calpain inhibitor IV

Formula: C₂₆H₄₁N₃O₅

Purity: By hplc: 99.17% (Typical Value in Batch COA)

Color and Shape: white to off-white solid

Molecular weight: 475.62g/mol

Ref: 54-BIC3742

MG-132

CAS: 133407-82-6

MG-132

Purity: ≥95%

Molecular weight: 475.62g/mol

Ref: 54-BUP17157

Z-Leu-Leu-Leu-al

CAS: 133407-82-6

Formula: C₂₆H₄₁N₃O₅

Purity: ≥ 97.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 475.63

Ref: 7W-GK3641

MG-132

CAS: 133407-82-6

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!

Formula: C₂₆H₄₁N₃O₅

Purity: 95% - 99.99%

Color and Shape: White To Off-White Powder

Molecular weight: 475.62

Ref: TM-T2154

MG 132

CAS: 133407-82-6

Stability Hygroscopic
Applications MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
References Lee, D., et al.: Trends in Cell Biol., 8, 397 (1998); Tsubuki, S., et al.: J. Biochem., 119., 572 (1996); Grimm, L., et al.: EMBO J., 15, 3835 (1996)

Formula: C₂₆H₄₁N₃O₅

Color and Shape: Neat

Molecular weight: 475.62

Ref: TR-M340900

Z-Leu-Leu-Leu-H (aldehyde)

CAS: 133407-82-6

Z-Leu-Leu-Leu-H (aldehyde) is an inhibitor that binds to a receptor and prevents the binding of a ligand. This competitive inhibition is reversible and can be used as a research tool to study protein interactions. The high purity of this product makes it ideal for use in pharmacology, cell biology, and life science research.

Formula: C₂₆H₄₁N₃O₅

Purity: Min. 95%

Molecular weight: 475.62 g/mol

Ref: 3D-IZL-3175-V

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln-EDDnp

CAS: 133407-82-6

Abz-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Gln (EDDNP) is a novel and potent inhibitor of the polymerase chain reaction (PCR). It has been shown to inhibit the activity of DNA polymerases, which are key enzymes in DNA replication. EDDNP binds to the active site of the enzyme and blocks access to the DNA template. In addition, this compound inhibits mitochondrial membrane potential, as well as transcriptional regulation and detoxification enzymes. This compound has also been shown to be effective in vivo in mouse models.

Formula: C₆₁H₉₁N₂₁O₁₉S₂

Purity: Min. 95%

Molecular weight: 1,486.66 g/mol

Ref: 3D-SFQ-3916-PI

MG 132

CAS: 133407-82-6

MG 132 is a modified tripeptide that acts as proteasomal inhibitor. In 2006, MG 132 has been experimentally tested in in vitro cell-based and in vivo models for to assess its use in the medical treatment of Parkinson's disease.

Formula: C₂₆H₄₁N₃O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 475.30462

Ref: 3D-FM29307