MPEG8-NH-Mal, or Methoxy Polyethylene Glycol (MPEG) with a molecular weight of approximately 8 kDa, is a derivative of polyethylene glycol (PEG) that features a maleimide functional group. This compound is characterized by its hydrophilic nature due to the presence of the polyethylene glycol backbone, which enhances solubility in aqueous environments. The maleimide group allows for specific conjugation reactions, making MPEG8-NH-Mal useful in bioconjugation applications, such as drug delivery systems and the development of biopharmaceuticals. The presence of the amine group (NH) provides additional reactivity, facilitating the formation of stable linkages with various biomolecules, including proteins and peptides. MPEG8-NH-Mal is typically utilized in the synthesis of polymer-drug conjugates, where it can improve the pharmacokinetics and bioavailability of therapeutic agents. Its biocompatibility and ability to form covalent bonds with thiol-containing compounds make it a valuable tool in the fields of medicinal chemistry and materials science.

m-PEG8-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.

MPEG8-NH-Mal

1334169-90-2: MPEG8-NH-Mal, or Methoxy Polyethylene Glycol (MPEG) with a molecular weight of approximately 8 kDa, is a derivative of polyethylene glycol (PEG) that features a maleimide functional group. This compound is characterized by its hydrophilic nature due to the presence of the polyethylene glycol backbone, which enhances solubility in aqueous environments. The maleimide group allows for specific conjugation reactions, making MPEG8-NH-Mal useful in bioconjugation applications, such as drug delivery systems and the development of biopharmaceuticals. The presence of the amine group (NH) provides additional reactivity, facilitating the formation of stable linkages with various biomolecules, including proteins and peptides. MPEG8-NH-Mal is typically utilized in the synthesis of polymer-drug conjugates, where it can improve the pharmacokinetics and bioavailability of therapeutic agents. Its biocompatibility and ability to form covalent bonds with thiol-containing compounds make it a valuable tool in the fields of medicinal chemistry and materials science.

m-PEG8-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

m-PEG8-Mal

<p>MAL-dPEG®8-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®8-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

CAS 1334169-90-2

MPEG8-NH-Mal

m-PEG8-Mal

Ref: TM-T15934

MAL-dPEG®8-TFP Ester

Ref: 3D-DPG-6221

CAS 1334169-90-2

MPEG8-NH-Mal

m-PEG8-Mal

Ref: TM-T15934

MAL-dPEG&reg;8-TFP Ester

Ref: 3D-DPG-6221

MAL-dPEG®8-TFP Ester