CAS 1334298-90-6: Itacitinib

Description: Itacitinib is a selective inhibitor of Janus kinase 1 (JAK1), which plays a crucial role in the signaling pathways of various cytokines and growth factors. This compound is primarily investigated for its therapeutic potential in treating autoimmune diseases and certain hematological malignancies. Itacitinib exhibits a favorable pharmacokinetic profile, characterized by good oral bioavailability and a manageable half-life, allowing for convenient dosing regimens. The substance is typically administered in a tablet form and has been studied in clinical trials for conditions such as ulcerative colitis and rheumatoid arthritis. Its mechanism of action involves the inhibition of JAK1-mediated signaling, which can lead to a reduction in inflammation and modulation of immune responses. As with many pharmacological agents, itacitinib's safety and efficacy profile is continuously evaluated, with attention to potential side effects, including infections and changes in blood cell counts. Overall, itacitinib represents a promising option in the landscape of targeted therapies for inflammatory and autoimmune disorders.

Synonyms:

• 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)i
• 1-[1-[[3-Fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

1-[1-[[3-Fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

CAS: 1334298-90-6

• Formula: C₂₆H₂₃F₄N₉O
• Purity: %
• Color and Shape: Solid
• Molecular weight: 553.5141

2-(3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-1-(1-(3-Fluoro-2-(Trifluoromethyl)Isonicotinoyl)Piperidin-4-Yl)Azetidin-3-Yl)Acetonitrile

CAS: 1334298-90-6

• Molecular weight: 553.51g/mol

Itacitinib

CAS: 1334298-90-6

• Purity: ≥95%
• Molecular weight: 553.51g/mol

Itacitinib

CAS: 1334298-90-6

Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic …

• Formula: C₂₆H₂₃F₄N₉O
• Purity: 96.4% - 99.01%
• Color and Shape: Solid
• Molecular weight: 553.51

Itacitinib

CAS: 1334298-90-6

Please enquire for more information about Itacitinib including the price, delivery time and more detailed …

• Formula: C₂₆H₂₃F₄N₉O
• Purity: Min. 95%
• Molecular weight: 553.51 g/mol