CAS 1334298-90-6

Itacitinib

Description:

Itacitinib is a selective inhibitor of Janus kinase 1 (JAK1), which plays a crucial role in the signaling pathways of various cytokines and growth factors. This compound is primarily investigated for its therapeutic potential in treating autoimmune diseases and certain hematological malignancies. Itacitinib exhibits a favorable pharmacokinetic profile, characterized by good oral bioavailability and a manageable half-life, allowing for convenient dosing regimens. The substance is typically administered in a tablet form and has been studied in clinical trials for conditions such as ulcerative colitis and rheumatoid arthritis. Its mechanism of action involves the inhibition of JAK1-mediated signaling, which can lead to a reduction in inflammation and modulation of immune responses. As with many pharmacological agents, itacitinib's safety and efficacy profile is continuously evaluated, with attention to potential side effects, including infections and changes in blood cell counts. Overall, itacitinib represents a promising option in the landscape of targeted therapies for inflammatory and autoimmune disorders.

Synonyms:

• 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)i
• 1-[1-[[3-Fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

1-[1-[[3-Fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

CAS: 1334298-90-6

Formula: C₂₆H₂₃F₄N₉O

Purity: %

Color and Shape: Solid

Molecular weight: 553.5141

Ref: IN-DA0039CO

2-(3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-1-(1-(3-Fluoro-2-(Trifluoromethyl)Isonicotinoyl)Piperidin-4-Yl)Azetidin-3-Yl)Acetonitrile

CAS: 1334298-90-6

2-(3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-1-(1-(3-Fluoro-2-(Trifluoromethyl)Isonicotinoyl)Piperidin-4-Yl)Azetidin-3-Yl)Acetonitrile

Purity: 98+%

Molecular weight: 553.51g/mol

Ref: 54-PC108724

Itacitinib

CAS: 1334298-90-6

Itacitinib

Purity: ≥95%

Molecular weight: 553.51g/mol

Ref: 54-BUP12909

Itacitinib

CAS: 1334298-90-6

Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.

Formula: C₂₆H₂₃F₄N₉O

Purity: 96.4% - 99.5%

Color and Shape: Solid

Molecular weight: 553.51

Ref: TM-T3998

Itacitinib

CAS: 1334298-90-6

Itacitinib is a Jak1 inhibitor that is used to treat bowel disease. Itacitinib has been shown to inhibit the growth of probiotic bacteria such as Lactobacillus and Bifidobacterium, which are beneficial for intestinal health. Itacitinib also inhibits the production of inflammatory cytokines, such as TNF-α, IL-6, and IL-8, in vitro in human monocytes. This drug has been shown to reduce the severity of bronchiolitis obliterans (a rare lung disease) in vivo in mice. Itacitinib binds to the cell factor on activated T cells and inhibits its signaling pathway. In addition, it blocks PD-L1 expression on tumor cells, thereby preventing tumor cell proliferation and inducing an M2 phenotype (a type of immune response). Finally, itacitinib inhibits Jak2 V617F activity by binding to this enzyme and causes a decrease in disease activity.

Formula: C₂₆H₂₃F₄N₉O

Purity: Min. 95%

Molecular weight: 553.51 g/mol

Ref: 3D-JDC29890