CAS 13345-50-1

PGA2

Description:

PGA2, or Prostaglandin A2, is a naturally occurring compound that belongs to the class of prostaglandins, which are lipid compounds derived from fatty acids. It plays a significant role in various physiological processes, including inflammation, blood flow regulation, and the modulation of immune responses. PGA2 is characterized by its ability to interact with specific receptors in the body, influencing cellular activities and signaling pathways. It is typically a colorless to pale yellow liquid and is sensitive to light and heat, which can affect its stability. The compound is soluble in organic solvents but has limited solubility in water. Due to its biological activity, PGA2 is of interest in pharmacological research, particularly in the context of cardiovascular health and inflammatory diseases. However, handling and usage require caution due to its potent biological effects. As with many prostaglandins, its synthesis and degradation are tightly regulated within biological systems, highlighting its importance in maintaining homeostasis.

Formula: C₂₀H₃₀O₄

InChI: InChI=1/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1

InChI key: InChIKey=MYHXHCUNDDAEOZ-FOSBLDSVSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)C=CC1=O

Synonyms:

• (+)-Prostaglandin A₂
• (15S)-PGA₂
• (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid
• 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostatrienoic acid
• 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoic acid
• 15(S)-Prostaglandin A₂
• 15-Hydroxy-9-Oxoprosta-5,10,13-Trien-1-Oic Acid
• 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienecarboxylic acid
• 15α-Hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoic acid
• 5,6-cis-PGA₂
• 5-Heptenoic acid, 7-[2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl]-
• Medullin
• NSC 165561
• PGA₂
• Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-
• Prostaglandin A2 solution
• Prostaglandin A2
• (5Z)-7-[(1R,2S)-2-[(1E,3S)-3-Hydroxy-1-octenyl]-5-oxo-3-cyclopenten-1-yl]-5-heptenoic acid
• pga(sup2)
• 7-(2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl)-5-heptenoicaci
• (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2
• 5,6-cis-pga(sup2)
• prostaglandina(sup2)
• (+)-prostaglandina(sup2)
• 9-OXO-15S-HYDROXY-PROSTA-5Z,10,13E-TRIEN-1-OIC ACID
• prostaglandin A(2) solution
• (155)-pga2
• PGA2 (Prostaglandin A2)
• PGA2
• 15-hydroxy-9-oxo-,(5z,13e,15s)-prosta-10-13-trien-1-oicacid
• Prostaglandin A2 solution,(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2
• (5Z,13E,15S)-15-Hydroxy-9-oxo-5,10,13-prostatrien-1-oic acid
• PROSTAGLANDINS A2

Prosta-5,10,13-trien-1-oicacid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-

CAS: 13345-50-1

Formula: C₂₀H₃₀O₄

Purity: 98%

Color and Shape: Liquid

Molecular weight: 334.4498

Ref: IN-DA0080H8

Dinoprostone EP Impurity D (Prostaglandin A2)

CAS: 13345-50-1

Formula: C₂₀H₃₀O₄

Molecular weight: 334.46

Ref: 4Z-D-250002

Prostaglandin A2

Controlled Product

CAS: 13345-50-1

Applications Prostaglandin A2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. Prostaglandin A2 is generally not present in mammals. Prostaglandin A2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. Prostaglandin A2 has also been shown to act as a vasodilator with natriuretic properties.
References Stenson, W., et al.: J. Immunol., 124, 2100 (1980), Bray, M., et al.: Prostaglandins, 22, 213 (1981), Funk, C., et al.: Science, 294, 1871 (2001), Newman, J., et al.: J. Lipid Res., 43, 1563 (2002), Blaho, V., et al.: J. Biol. Chem., 284, 21599 (2009),

Formula: C₂₀H₃₀O₄

Color and Shape: Neat

Molecular weight: 334.45

Ref: TR-P838550

Prostaglandin A6

CAS: 13345-50-1

Prostaglandin A6 is a lipid mediator that is involved in the regulation of many physiological and pathological processes. It has been shown to inhibit the activity of ion channels, increase the permeability of cell membranes, and activate G protein-coupled receptors. Prostaglandin A6 has been extensively used as an inhibitor in research tools for studying cell biology, peptides, pharmacology, ligand binding, and protein interactions. In addition, prostaglandin A6 is a potent activator of G protein-coupled receptors that are found in cardiovascular tissues. This compound also inhibits platelet aggregation and activates vasodilatory pathways.

Formula: C₂₀H₃₀O₄

Purity: Min. 95%

Molecular weight: 334.4 g/mol

Ref: 3D-BP180569

Dinoprostone EP Impurity D

CAS: 13345-50-1

Formula: C₂₀H₃₀O₄

Molecular weight: 334.5

Ref: ST-EA-CP-D117004

Prostaglandin A2

CAS: 13345-50-1

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]

Formula: C₂₀H₃₀O₄

Color and Shape: Solid

Molecular weight: 334.45

Ref: TM-T36542