CAS 133525-01-6

3'-azido-3'-deoxythymidine B-D-*glucuronide sodiu

Description:

3'-Azido-3'-deoxythymidine B-D-glucuronide sodium, commonly known as AZT glucuronide, is a derivative of the antiretroviral drug zidovudine (AZT). This compound features an azido group at the 3' position of the deoxythymidine backbone, which is crucial for its activity against retroviruses, particularly HIV. The glucuronide moiety indicates that the compound has undergone a conjugation reaction, typically enhancing its solubility and facilitating excretion. As a sodium salt, it is likely to be more soluble in aqueous solutions, making it suitable for various pharmaceutical applications. The compound is characterized by its antiviral properties, specifically its ability to inhibit viral replication by interfering with reverse transcriptase, an enzyme critical for the life cycle of retroviruses. Additionally, the glucuronidation process may influence its pharmacokinetics, potentially affecting its bioavailability and therapeutic efficacy. Overall, 3'-azido-3'-deoxythymidine B-D-glucuronide sodium represents an important modification of a key antiviral agent, contributing to the ongoing research in HIV treatment and management.

Formula: C₁₆H₂₀N₅NaO₁₀

InChI: InChI=1/C16H21N5O10.Na/c1-5-3-21(16(28)18-13(5)25)8-2-6(19-20-17)7(30-8)4-29-15-11(24)9(22)10(23)12(31-15)14(26)27;/h3,6-12,15,22-24H,2,4H2,1H3,(H,26,27)(H,18,25,28);/q;+1/p-1/t6-,7-,8-,9+,10+,11+,12?,15-;/m1./s1

SMILES: Cc1cn(C2CC(C(COC3C(C(C(C(C(=O)O)O3)O)O)O)O2)N=[N+]=[NH-])c(=O)nc1O.[Na]

Synonyms:

• 3-Azido-3-deoxythymidine -D-glucuronide, Sodium Salt
• Zidovudine Glucuronide SodiuM Salt
• zidovudine beta-D-glucuronide
• 3'-AZIDO-3'-DEOXYTHYMIDINE B-D-GLUCURONIDE, SODIUM SALT
• 3'-Azido-3'-deoxy-D-thymidine-b-D-glucuronidesodiumsalt
• 3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT
• Zidovudine Glucuronide
• 3'-Azido-3'-deoxy-5'-O-β-D-glucopyranuronosylthymidine
• (3'-Deoxy-3'-azido-5'-thymidyl)-β-D-glucopyranosiduronic acid
• 3'-azido-3'-deoxythymidine B-D-*glucuronide sodiu
• 3'-AZIDO-3'-DEOXYTHYMIDINE O-D-GLUCURONIDE SODIUM SALT
• AZT Glucuronide SodiuM Salt
• (3'-Azido-3'-deoxy-5'-thymidyl)β-D-glucopyranosiduronic acid
• AZT GLUCURONIDE
• AZT-G
• 3'-Azido-3'-deoxy-5'-O-β-D-glucopyranuronosyl-thyMidine MonosodiuM Salt

3''-Azido-3''-deoxythymidine-b-D-glucuronide sodium salt

CAS: 133525-01-6

Ref: 7W-GN0932

Zidovudine Glucuronide Sodium Salt

CAS: 133525-01-6

Formula: C₁₆H₂₀N₅O₁₀·Na

Molecular weight: 442.36 22.99

Ref: 4Z-Z-0811

3'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt

Controlled Product

CAS: 133525-01-6

Stability Hygroscopic
Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.

Formula: C₁₆H₂₀N₅O₁₀·Na

Color and Shape: White To Light Yellow

Molecular weight: 465.35

Ref: TR-A825050

3'-Azido-3'-deoxythymidine-methyl-d3 β-D-glucuronide, Sodium Salt

Controlled Product

CAS: 133525-01-6

Applications A deuterated metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.This compounds contains Sodium Chloride. Water content not determined.

Formula: C₁₆D₃H₁₇N₅O₁₀·Na

Color and Shape: Neat

Molecular weight: 468.3658

Ref: TR-A825052

3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt

CAS: 133525-01-6

3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt is an antiviral and anticancer agent that inhibits the synthesis of DNA, RNA, and protein. It has shown to be effective against a variety of viruses including HIV-1, herpes simplex virus type 1, influenza A virus, vaccinia virus, and vesicular stomatitis virus. 3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt also inhibits the growth of cancer cells in vitro. This drug is a modified nucleoside with a phosphoramidite backbone and a 3'-azido group at one end. The other end contains a beta D glucuronic acid moiety. The modifications allow for the inhibition of DNA synthesis by blocking the incorporation of deoxyribonucleotides into DNA chains.

Formula: C₁₆H₂₀N₅NaO₁₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 465.35 g/mol

Ref: 3D-NA06316