CAS 133577-33-0

2'-Epi Docetaxel

Description:

2'-Epi Docetaxel, with the CAS number 133577-33-0, is a semi-synthetic derivative of the natural product taxol (paclitaxel), which is derived from the bark of the Pacific yew tree. This compound is primarily known for its application in cancer therapy, particularly in the treatment of breast, lung, and prostate cancers. Structurally, 2'-Epi Docetaxel features a modified taxane core, which enhances its pharmacological properties, including improved solubility and bioavailability compared to its parent compound. The mechanism of action involves the stabilization of microtubules, thereby inhibiting cell division and promoting apoptosis in rapidly dividing cancer cells. Additionally, 2'-Epi Docetaxel exhibits a favorable safety profile, although it can still cause side effects typical of chemotherapeutic agents, such as neutropenia and gastrointestinal disturbances. Its development reflects ongoing efforts to optimize taxane-based therapies, aiming to improve efficacy while minimizing adverse effects in cancer treatment regimens.

Formula: C₄₃H₅₃NO₁₄

Synonyms:

• Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cycl
• Benzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aS*,bS*),11a,12a,12a,12ba]]-
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 2'-epi-Taxotere

2-Epi Docetaxel

CAS: 133577-33-0

Formula: C₄₃H₅₃NO₁₄

Molecular weight: 807.89

Ref: 4Z-D-1913

2’-Epi Docetaxel

Controlled Product

CAS: 133577-33-0

Applications An impurity of Docetaxel (D494420).
References Zamir, L., et al.: Tetrahedron Lett., 33, 5173 (1992), Gueritte-Voegelein, F., et al.: J. Med. Chem., 34, 992 (1993), Volk, K., et al.: J. Chromatogr., 696, 99 (1997),

Formula: C₄₃H₅₃NO₁₄

Color and Shape: Neat

Molecular weight: 807.88

Ref: TR-E588600

2-Epi Docetaxel Impurity

CAS: 133577-33-0

Formula: C₄₃H₅₃NO₁₄

Molecular weight: 807.9

Ref: ST-EA-CP-D32011