CAS 133627-47-1: 3-PyridineCarboxamide,Nevirapine

Description: 3-Pyridinecarboxamide, also known as Nevirapine, is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the non-nucleoside reverse transcriptase inhibitor (NNRTI) class, which works by inhibiting the reverse transcriptase enzyme, thereby preventing viral replication. The chemical structure features a pyridine ring, which contributes to its pharmacological properties. Nevirapine is characterized by its moderate lipophilicity, allowing it to penetrate cell membranes effectively. It is typically administered orally and is known for its relatively rapid absorption and distribution in the body. The drug is metabolized primarily in the liver, with a significant portion undergoing first-pass metabolism. Nevirapine has a well-established safety profile, although it can cause side effects such as rash and liver toxicity in some patients. Its use is often part of combination therapy to enhance efficacy and reduce the risk of resistance. Overall, Nevirapine remains a critical component in the management of HIV/AIDS, particularly in resource-limited settings.

Formula: C₁₅H₁₅ClN₄O

InChI: InChI=1S/C15H15ClN4O/c1-9-6-8-17-13(16)12(9)20-15(21)11-3-2-7-18-14(11)19-10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,19)(H,20,21)

InChI key: InChIKey=GURGGHUREHGAMI-UHFFFAOYSA-N

SMILES: O=C(NC=1C(Cl)=NC=CC1C)C2=CC=CN=C2NC3CC3

Synonyms:

• 3-Pyridinecarboxamide, N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-
• Cyclor
• N-(2-Chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide
• N-(2-Lhioro-4-Methyi-J-Pyndinyl)-2-(Cyclopropyi Amino)-3-Pyridine Carboxamide

3-PyridineCarboxamide,Nevirapine

CAS: 133627-47-1

• Formula: C₁₅H₁₅ClN₄O
• Purity: 98%
• Molecular weight: 302.7588

N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide

CAS: 133627-47-1

• Purity: 98%
• Molecular weight: 302.760009765625

N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide

CAS: 133627-47-1

• Formula: C₁₅H₁₅ClN₄O
• Color and Shape: Neat
• Molecular weight: 302.759

N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide

CAS: 133627-47-1

N-(2-Chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)nicotinamide is a quinoline derivative that inhibits HIV replication by blocking the reverse transcriptase enzyme. …

• Formula: C₁₅H₁₅ClN₄O
• Purity: Min. 95%
• Molecular weight: 302.76 g/mol