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CAS 133627-47-1

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3-PyridineCarboxamide,Nevirapine

Description:
3-Pyridinecarboxamide, also known as Nevirapine, is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the non-nucleoside reverse transcriptase inhibitor (NNRTI) class, which works by inhibiting the reverse transcriptase enzyme, thereby preventing viral replication. The chemical structure features a pyridine ring, which contributes to its pharmacological properties. Nevirapine is characterized by its moderate lipophilicity, allowing it to penetrate cell membranes effectively. It is typically administered orally and is known for its relatively rapid absorption and distribution in the body. The drug is metabolized primarily in the liver, with a significant portion undergoing first-pass metabolism. Nevirapine has a well-established safety profile, although it can cause side effects such as rash and liver toxicity in some patients. Its use is often part of combination therapy to enhance efficacy and reduce the risk of resistance. Overall, Nevirapine remains a critical component in the management of HIV/AIDS, particularly in resource-limited settings.
Formula:C15H15ClN4O
InChI:InChI=1S/C15H15ClN4O/c1-9-6-8-17-13(16)12(9)20-15(21)11-3-2-7-18-14(11)19-10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,19)(H,20,21)
InChI key:InChIKey=GURGGHUREHGAMI-UHFFFAOYSA-N
SMILES:N(C1=C(C(NC=2C(C)=CC=NC2Cl)=O)C=CC=N1)C3CC3
Synonyms:
  • 3-Pyridinecarboxamide, N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-
  • Cyclor
  • N-(2-Chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide
  • N-(2-Lhioro-4-Methyi-J-Pyndinyl)-2-(Cyclopropyi Amino)-3-Pyridine Carboxamide
  • N-(2-Chioro-4-Methyi-3-Pyndinyl)-2-(Cyclopropyi AMino)-3-Pyridine CarboxaMide
  • 3-PyridineCarboxamide,Nevirapine
  • Nevirapine Impurity 1
  • Naproxen Impurity 49
  • N-(2-chloro-4-methylpyridin-3-yl)-2-(cyclopropylamino)pyridine-3-carboxamide
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