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CAS 133695-76-8

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DSPE-Biotin

Description:
DSPE-Biotin, or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl) (ammonium salt), is a phospholipid derivative that incorporates biotin, a vitamin known for its role in cellular metabolism and as a cofactor for carboxylase enzymes. This compound is characterized by its amphiphilic nature, possessing both hydrophilic (the biotin moiety) and hydrophobic (the distearoyl glycerol backbone) regions, which allows it to form lipid bilayers or micelles in aqueous environments. DSPE-Biotin is commonly used in bioconjugation applications, particularly in the development of targeted drug delivery systems and in the preparation of liposomes for biomedical research. Its ability to bind specifically to streptavidin or avidin makes it a valuable tool in various biochemical assays and imaging techniques. Additionally, the stability of the distearoyl chain contributes to the overall robustness of formulations that incorporate this lipid, making it suitable for various pharmaceutical and diagnostic applications.
Synonyms:
  • Octadecanoic acid, (1R)-1-[12-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-3-hydroxy-3-oxido-8-oxo-2,4-dioxa-7-aza-3-phosphadodec-1-yl]-1,2-ethanediyl ester
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