CAS 133737-32-3

Pagoclone

Description:

Pagoclone is a chemical compound that belongs to the class of anxiolytics, primarily investigated for its potential use in treating anxiety disorders. It acts as a selective modulator of the GABA-A receptor, which is a key player in the central nervous system's inhibitory neurotransmission. Pagoclone is characterized by its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to anxiolytic effects without the sedative properties commonly associated with traditional benzodiazepines. The compound has a relatively low affinity for other receptor types, which may contribute to a more favorable side effect profile. Pagoclone is typically administered in oral form and has been the subject of various clinical studies to evaluate its efficacy and safety. Its pharmacokinetics suggest a moderate half-life, allowing for once or twice daily dosing. However, as with any pharmacological agent, the potential for side effects and interactions with other medications should be carefully considered in clinical settings.

Formula: C₂₃H₂₂ClN₃O₂

InChI: InChI=1/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3

InChI key: InChIKey=HIUPRQPBWVEQJJ-UHFFFAOYNA-N

SMILES: C(C(CCC(C)C)=O)C1N(C(=O)C=2C1=CC=CC2)C3=NC4=C(C=C3)C=CC(Cl)=N4

Synonyms:

• (+)-2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-1H-isoindol-1-one
• 1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-, (+)-
• 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one
• Ip 456
• Rp 59037
• Rp 62955
• Pagoclone

Pagoclone

Controlled Product

CAS: 133737-32-3

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability. Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition.

Purity: Min. 95%

Ref: 3D-BP177437