CAS 1337531-36-8

7-Methyl-5-[1-[[3-(trifluoromethyl)phenyl]acetyl]-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Description:

7-Methyl-5-[1-[[3-(trifluoromethyl)phenyl]acetyl]-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups and heterocycles. The presence of a trifluoromethyl group indicates potential for significant lipophilicity and biological activity, often enhancing the compound's pharmacological properties. The indole and pyrrolopyrimidine moieties suggest potential interactions with biological targets, making it of interest in medicinal chemistry. This compound may exhibit properties such as anti-inflammatory or anticancer activities, typical of many indole derivatives. Its synthesis likely involves multi-step organic reactions, and it may be evaluated for its solubility, stability, and reactivity under various conditions. The CAS number 1337531-36-8 uniquely identifies this substance in chemical databases, facilitating research and regulatory considerations. Overall, the compound's structural complexity and functional diversity position it as a candidate for further investigation in drug development and therapeutic applications.

Formula: C₂₄H₂₀F₃N₅O

InChI: InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)

InChI key: InChIKey=SIXVRXARNAVBTC-UHFFFAOYSA-N

SMILES: NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4

Synonyms:

• GSK 2606414
• 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
• 7-Methyl-5-[1-[[3-(trifluoromethyl)phenyl]acetyl]-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
• Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]-

7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine

CAS: 1337531-36-8

Formula: C₂₄H₂₀F₃N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 451.4437

Ref: IN-DA009CC2

GSK2606414

CAS: 1337531-36-8

GSK2606414

Purity: ≥98%

Molecular weight: 451.44g/mol

Ref: 54-BUP14839

GSK2606414

CAS: 1337531-36-8

GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.

Formula: C₂₄H₂₀F₃N₅O

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 451.44

Ref: TM-T2614

GSK2606414

CAS: 1337531-36-8

Ref: 7W-GE1408

GSK 2606414

CAS: 1337531-36-8

Inhibitor of EIF2AK3/PERK kinases

Formula: C₂₄H₂₀F₃N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 451.44 g/mol

Ref: 3D-FG65036

GSK 2606414-d3

Controlled Product

CAS: 1337531-36-8

Formula: C₂₄D₃H₁₉F₃N₅O

Color and Shape: Neat

Molecular weight: 456.478

Ref: TR-G797512

GSK 2606414

Controlled Product

CAS: 1337531-36-8

Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.
References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);

Formula: C₂₄H₂₀F₃N₅O

Color and Shape: Neat

Molecular weight: 451.44

Ref: TR-G797510