CAS 1337531-89-1

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

CAS: 1337531-89-1

Formula: C₂₄H₁₉F₄N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.4342

Ref: IN-DA009ET4

PERK-IN-4

CAS: 1337531-89-1

PERK-IN-4

Purity: ≥98%

Molecular weight: 469.43g/mol

Ref: 54-BUP07493

PERK-IN-4

CAS: 1337531-89-1

PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.

Formula: C₂₄H₁₉F₄N₅O

Purity: 99.44% - 99.49%

Color and Shape: Solid

Molecular weight: 469.43

Ref: TM-T38732

GSK PERK Inhibitor

Controlled Product

CAS: 1337531-89-1

Applications GSK PERK Inhibitor is an inhibitor of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways. As a result, GSK PERK Inhibitor has potential use in the treatment of diseases such as Alzheimer's disease, stroke, Type 1 diabetes, Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung.
References Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007); Axten, J. M.et al,: J. Med. Chem. 55(16) 7193 (2012).

Formula: C₂₄H₁₉F₄N₅O

Color and Shape: Neat

Molecular weight: 469.43

Ref: TR-G797800

GSK PERK Inhibitor-d3

Controlled Product

CAS: 1337531-89-1

Formula: C₂₄D₃H₁₆F₄N₅O

Color and Shape: Neat

Molecular weight: 472.453

Ref: TR-G797802

GSK PERK inhibitor

CAS: 1337531-89-1

Inhibitor of EIF2AK3/PERK kinases

Formula: C₂₄H₁₉F₄N₅O

Purity: Min. 95%

Molecular weight: 469.43 g/mol

Ref: 3D-FG23705