CAS 1337532-29-2: 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone

Description: 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone, with CAS number 1337532-29-2, is a complex organic compound characterized by its multi-cyclic structure, which includes pyrimidine, indole, and pyridine moieties. This compound features a fluorine atom, which can influence its reactivity and biological activity. The presence of an amino group suggests potential for hydrogen bonding and interaction with biological targets, making it of interest in medicinal chemistry. The methyl groups contribute to its lipophilicity, potentially affecting its pharmacokinetic properties. As a synthetic compound, it may exhibit specific biological activities, possibly as an inhibitor or modulator in various biochemical pathways. Its structural complexity indicates that it may have unique interactions with enzymes or receptors, warranting further investigation in drug development contexts. Overall, this compound exemplifies the intricate design often found in pharmaceutical agents aimed at targeting specific biological processes.

Formula: C₂₃H₂₁FN₆O

InChI: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)

InChI key: InChIKey=PRWSIEBRGXYXAJ-UHFFFAOYSA-N

SMILES: O=C(N1C=2C=CC(=C(F)C2CC1)C3=CN(C=4N=CN=C(N)C43)C)CC5=NC(=CC=C5)C

Synonyms:

• 5-[4-Fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-
• PERK inhibitor II
• GSK 2656157
• 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone

GSK2656157

CAS: 1337532-29-2

• Formula: C₂₃H₂₁FN₆O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 416.4508

GSK2656157

CAS: 1337532-29-2

• Purity: 97.77%
• Molecular weight: 416.45g/mol

GSK2656157

CAS: 1337532-29-2

GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free …

• Formula: C₂₃H₂₁FN₆O
• Purity: 100% - 99.89%
• Color and Shape: Solid
• Molecular weight: 416.45

GSK2656157

CAS: 1337532-29-2

Applications GSK2656157 is an ATP-competitive and highly selective inhibitor of PKR-like endoplasmic reticulum kinase (PERK) …

• Formula: C₂₃H₂₁FN₆O
• Color and Shape: Neat
• Molecular weight: 416.45

5-[4-Fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CAS: 1337532-29-2

5-[4-Fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a melatonin analog that is under development for the treatment of human osteosarcoma …

• Formula: C₂₃H₂₁FN₆O
• Purity: Min. 95%
• Molecular weight: 416.45 g/mol