CAS 1337532-29-2

1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone

Description:

1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone, with CAS number 1337532-29-2, is a complex organic compound characterized by its multi-cyclic structure, which includes pyrimidine, indole, and pyridine moieties. This compound features a fluorine atom, which can influence its reactivity and biological activity. The presence of an amino group suggests potential for hydrogen bonding and interaction with biological targets, making it of interest in medicinal chemistry. The methyl groups contribute to its lipophilicity, potentially affecting its pharmacokinetic properties. As a synthetic compound, it may exhibit specific biological activities, possibly as an inhibitor or modulator in various biochemical pathways. Its structural complexity indicates that it may have unique interactions with enzymes or receptors, warranting further investigation in drug development contexts. Overall, this compound exemplifies the intricate design often found in pharmaceutical agents aimed at targeting specific biological processes.

Formula: C₂₃H₂₁FN₆O

InChI: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)

InChI key: InChIKey=PRWSIEBRGXYXAJ-UHFFFAOYSA-N

SMILES: NC1=C2C(=CN(C)C2=NC=N1)C=3C(F)=C4C(=CC3)N(C(CC=5N=C(C)C=CC5)=O)CC4

Synonyms:

• 5-[4-Fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-
• PERK inhibitor II
• GSK 2656157
• 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone

GSK2656157

CAS: 1337532-29-2

Formula: C₂₃H₂₁FN₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.4508

Ref: IN-DA009CC4

GSK2656157

CAS: 1337532-29-2

GSK2656157

Purity: ≥95%

Molecular weight: 416.45g/mol

Ref: 54-BUP10060

GSK2656157

CAS: 1337532-29-2

GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.

Formula: C₂₃H₂₁FN₆O

Purity: 98.59% - >99.99%

Color and Shape: Solid

Molecular weight: 416.45

Ref: TM-T2654

GSK2656157

Controlled Product

CAS: 1337532-29-2

Applications GSK2656157 is an ATP-competitive and highly selective inhibitor of PKR-like endoplasmic reticulum kinase (PERK) enzyme activity. GSK2656157 also has anti-tumor and anti-angiogenic activity.
References Axten, J.M., et al.: ACS Med. Chem. Lett., 4, 964 (2013); Atkins, C., et al.: Cancer Res., 73, 1993 (2013)

Formula: C₂₃H₂₁FN₆O

Color and Shape: Neat

Molecular weight: 416.45

Ref: TR-G797515