CAS 13379-87-8

Tiprenolol hydrochloride

Description:

Tiprenolol hydrochloride is a beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension. As a non-selective beta-blocker, it works by reducing intraocular pressure through decreased aqueous humor production. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for formulation in eye drops. Its chemical structure includes a naphthalene ring, which contributes to its pharmacological activity. Tiprenolol hydrochloride is typically administered topically in the form of ophthalmic solutions. The compound's mechanism of action involves blocking beta-adrenergic receptors, which leads to a reduction in heart rate and myocardial contractility, although its primary application is in ophthalmology. Safety and efficacy profiles are well-documented, with common side effects including ocular irritation and systemic effects related to beta-blockade. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing or using Tiprenolol hydrochloride.

Formula: C₁₃H₂₂ClNO₂S

InChI: InChI=1/C13H21NO2S.ClH/c1-10(2)14-8-11(15)9-16-12-6-4-5-7-13(12)17-3;/h4-7,10-11,14-15H,8-9H2,1-3H3;1H

InChI key: InChIKey=PZWMMXHCUXTDQM-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C(SC)C=CC=C1.Cl

Synonyms:

• 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(methylthio)phenoxy]-, hydrochloride (1:1)
• 2-Propanol, 1-(isopropylamino)-3-[o-(methylthio)phenoxy]-, hydrochloride
• DU 21445 HCl
• 2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(methylthio)phenoxy]-, hydrochloride
• Tiprenolol hydrochloride
• 2-hydroxy-N-(1-methylethyl)-3-[2-(methylsulfanyl)phenoxy]propan-1-aminium chloride
• (2-Hydroxy-3-(2-(methylthio)phenoxy)propyl)isopropylammonium chloride

Tiprenolol hydrochloride

CAS: 13379-87-8

Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.

Formula: C₁₃H₂₂ClNO₂S

Color and Shape: Solid

Molecular weight: 291.84

Ref: TM-T201760