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CAS 1338055-88-1

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Colistin B Sulfate Salt (~90%)

Description:
Colistin B sulfate salt is an antibiotic substance derived from the bacterium *Bacillus polymyxa*. It belongs to the polymyxin class of antibiotics, which are primarily effective against Gram-negative bacteria. Colistin B is known for its ability to disrupt bacterial cell membranes, leading to cell death, making it a valuable treatment option for multidrug-resistant infections. The sulfate salt form enhances its solubility in aqueous solutions, facilitating its use in clinical settings. Colistin B sulfate is typically administered via intravenous or inhalation routes, especially in severe infections caused by resistant strains such as *Pseudomonas aeruginosa*. Its use, however, is often limited by potential nephrotoxicity and neurotoxicity, necessitating careful monitoring of renal function during treatment. Additionally, the emergence of colistin resistance among bacteria poses a significant challenge in antibiotic therapy. Overall, while Colistin B sulfate remains a critical option in the antibiotic arsenal, its application must be judiciously managed to mitigate adverse effects and resistance development.
Formula:C52H100N16O17S
Synonyms:
  • Colistin B Sulfate Salt (~90%)
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