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CAS 1338225-97-0

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Doravirine

Description:
Doravirine is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of the virus. Doravirine is characterized by its high selectivity for the HIV-1 enzyme, which helps minimize off-target effects and potential toxicity. The compound exhibits a favorable pharmacokinetic profile, allowing for once-daily dosing without the need for food restrictions. Its chemical structure includes a bicyclic core, contributing to its stability and efficacy against various HIV strains, including those resistant to other NNRTIs. Doravirine has been shown to have a lower incidence of central nervous system side effects compared to older NNRTIs, making it a preferred option for many patients. Additionally, it is often used in combination with other antiretroviral agents to enhance therapeutic effectiveness and reduce the risk of resistance development. Overall, Doravirine represents a significant advancement in HIV treatment regimens.
Formula:C17H11ClF3N5O3
InChI:InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
InChI key:InChIKey=ZIAOVIPSKUPPQW-UHFFFAOYSA-N
SMILES:O(C1=C(C(F)(F)F)C=CN(CC=2N(C)C(=O)NN2)C1=O)C3=CC(C#N)=CC(Cl)=C3
Synonyms:
  • 3-Chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile
  • Doravirine
  • MK 1439
  • 3-Chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile
  • Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-
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