CAS 1338247-35-0

Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-

Description:

Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl- is a synthetic organic compound characterized by its complex structure, which includes a propanamide functional group, a thiazole ring, and a pyrazole moiety. The presence of the 2,6-dichlorophenyl group and difluoromethyl substituent contributes to its unique chemical properties and potential biological activity. This compound may exhibit specific interactions with biological targets, making it of interest in medicinal chemistry and drug development. Its molecular structure suggests potential applications in areas such as agrochemicals or pharmaceuticals, particularly in the development of compounds with anti-inflammatory or anti-cancer properties. The compound's solubility, stability, and reactivity would depend on its specific functional groups and overall molecular configuration. As with many synthetic compounds, safety and handling precautions are essential due to potential toxicity or environmental impact. Further studies would be necessary to fully elucidate its properties and applications.

Formula: C₁₇H₁₄Cl₂F₂N₄OS

InChI: InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)

InChI key: InChIKey=IVUGBSGLHRJSSP-UHFFFAOYSA-N

SMILES: ClC1=C(N2C(=CC(C(F)F)=N2)C=3SC(NC(C(C)C)=O)=NC3)C(Cl)=CC=C1

Synonyms:

• Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-
• BMS 5

N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide

CAS: 1338247-35-0

Formula: C₁₇H₁₄Cl₂F₂N₄OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 431.2871

Ref: IN-DA009CM3

BMS-5

CAS: 1338247-35-0

BMS-5

Purity: ≥95%

Molecular weight: 431.29g/mol

Ref: 54-BUP08643

BMS-5

CAS: 1338247-35-0

BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.

Formula: C₁₇H₁₄Cl₂F₂N₄OS

Purity: 98.01% - 99.88%

Color and Shape: Solid

Molecular weight: 431.29

Ref: TM-T4598

BMS-5

CAS: 1338247-35-0

Ref: 7W-GW8582

BMS-5

CAS: 1338247-35-0

Purity: 98%

Molecular weight: 430.023

Ref: 10-F863287

LIMKi 3

Controlled Product

CAS: 1338247-35-0

Applications LIMKi 3 is a LIM kinase 1 (LIMK1) inhibitor that has antitumor properties.
References Charkrabarti, R.; et al.: PCT Int. Appl. 46pp. Patent 2013 CODEN:PIXXD2

Formula: C₁₇H₁₄Cl₂F₂N₄OS

Color and Shape: Neat

Molecular weight: 431.287

Ref: TR-L397688

LIMKi 3

CAS: 1338247-35-0

LIMKi 3 is a sesquiterpene lactone that has been shown to activate the LIM kinase pathway. This pathway is involved in axonal growth, neuronal differentiation, and apoptosis. It has been shown to induce apoptosis in HL-60 cells and malignant brain cells. LIMKi 3 also inhibits HIV infection by interrupting the production of effector proteins such as tat and rev, which are necessary for viral replication. The compound has potent antitumor activity against human tumor cell lines in vitro and in vivo with no observed toxicity to normal tissues.

Formula: C₁₇H₁₄Cl₂F₂N₄OS

Purity: Min. 95%

Molecular weight: 431.29 g/mol

Ref: 3D-NDC24735