CAS 133841-13-1

1-Methyl-7-(phenylmethoxy)-1H-indazole-3-carboxylic acid

Description:

1-Methyl-7-(phenylmethoxy)-1H-indazole-3-carboxylic acid is a chemical compound characterized by its indazole core, which is a five-membered heterocyclic structure containing two nitrogen atoms. The presence of a methyl group at the 1-position and a phenylmethoxy group at the 7-position contributes to its unique properties. This compound features a carboxylic acid functional group at the 3-position, which is indicative of its potential acidity and reactivity. The phenylmethoxy substituent enhances its lipophilicity, potentially influencing its solubility and biological activity. The compound may exhibit various pharmacological properties, making it of interest in medicinal chemistry. Its molecular structure suggests potential interactions with biological targets, which could be explored in drug development. Additionally, the presence of both aromatic and heteroaromatic components may contribute to its stability and reactivity under different conditions. Overall, 1-Methyl-7-(phenylmethoxy)-1H-indazole-3-carboxylic acid represents a complex structure with potential applications in various fields, including pharmaceuticals and organic synthesis.

Formula: C₁₆H₁₄N₂O₃

InChI: InChI=1S/C16H14N2O3/c1-18-15-12(14(17-18)16(19)20)8-5-9-13(15)21-10-11-6-3-2-4-7-11/h2-9H,10H2,1H3,(H,19,20)

InChI key: InChIKey=FUMWDAXDEQWIQK-UHFFFAOYSA-N

SMILES: O(CC1=CC=CC=C1)C2=C3C(C(C(O)=O)=NN3C)=CC=C2

Synonyms:

• 1H-Indazole-3-carboxylic acid, 1-methyl-7-(phenylmethoxy)-
• 1-Methyl-7-(phenylmethoxy)-1H-indazole-3-carboxylic acid

7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic Acid

Controlled Product

CAS: 133841-13-1

Applications 7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic Acid is an intermediate in the synthesis of 7-Hydroxy Granisetron (H942675), a metabolite of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor.
References Bloomer, J., et al.: Brit. J. Clin. Pharmacol., 38, 557 (1994); Vernekar, S.,e t al.: J. Med. Chem., 53, 2324 (2010); Kilpatrick, G.J., et al.: Nature, 330, 746 (1987); Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997); Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996)

Formula: C₁₆H₁₄N₂O₃

Color and Shape: Neat

Molecular weight: 282.29

Ref: TR-B286785

7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic acid

Controlled Product

CAS: 133841-13-1

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Formula: C₁₆H₁₄N₂O₃

Purity: Min. 95%

Molecular weight: 282.29 g/mol

Ref: 3D-IFA84113