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CAS 133852-23-0

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Fmoc-Tyr-OtBu

Description:
Fmoc-Tyr-OtBu, or 9-fluorenylmethoxycarbonyl-tyrosine tert-butyl ester, is a protected form of the amino acid tyrosine, commonly used in peptide synthesis. The Fmoc group serves as a protective group for the amino functionality, allowing for selective reactions without interfering with the side chain. The tert-butyl ester protects the hydroxyl group of the tyrosine side chain, enhancing the stability and solubility of the compound during synthesis. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Fmoc-Tyr-OtBu is crucial in solid-phase peptide synthesis, where it facilitates the stepwise assembly of peptides while maintaining the integrity of the functional groups. Its stability under basic conditions makes it suitable for various coupling reactions. The compound is also characterized by its relatively high molecular weight and specific reactivity patterns, which are essential for the successful synthesis of complex peptides and proteins in research and pharmaceutical applications.
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