CAS 1338824-21-7

ML224

CAS: 1338824-21-7

ML224

Purity: ≥98%

Molecular weight: 525.59g/mol

Ref: 54-BUP00433

ML224

CAS: 1338824-21-7

ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.

Formula: C₃₁H₃₁N₃O₅

Purity: 99.14%

Color and Shape: Solid

Molecular weight: 525.59

Ref: TM-T16106

ML224

CAS: 1338824-21-7

ML224 is a ryanodine receptor antagonist that has been shown to be effective in the treatment of cardiac disease. ML224 is a selective, competitive antagonist of the ryanodine receptor. It blocks calcium release from the sarcoplasmic reticulum, which leads to decreased intracellular calcium concentrations and reduced contractility. This drug has also been shown to have anti-inflammatory properties by inhibiting IL-10 production. ML224 has also been shown to inhibit acetylcholinesterase activity, leading to increased acetylcholine levels at synapses in the central and peripheral nervous systems. This may contribute to its ability to increase blood pressure and heart rate.

Formula: C₃₁H₃₁N₃O₅

Purity: Min. 95%

Molecular weight: 525.59 g/mol

Ref: 3D-NDC82421