CAS 134-05-4

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](formyl)amino}phenyl)carbonyl]-L-glutamic acid

Description:

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](formyl)amino}phenyl)carbonyl]-L-glutamic acid, commonly known as Methotrexate, is a potent antimetabolite and antifolate drug primarily used in the treatment of certain cancers and autoimmune diseases. It functions by inhibiting dihydrofolate reductase, an enzyme critical for DNA synthesis and cell replication, thereby impeding the growth of rapidly dividing cells. Methotrexate is characterized by its complex structure, which includes a pteridine ring, an amino acid moiety, and a carboxylic acid group, contributing to its solubility and biological activity. The compound exhibits a range of pharmacokinetic properties, including absorption, distribution, metabolism, and excretion that can vary based on dosage and administration route. Its therapeutic effects are often accompanied by side effects, necessitating careful monitoring during treatment. Methotrexate is also utilized in lower doses for chronic inflammatory conditions, showcasing its versatility in medical applications.

Formula: C₂₀H₁₉N₇O₇

InChI: InChI=1/C20H19N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,7,9,13H,5-6,8H2,(H,24,31)(H,29,30)(H,33,34)(H3,21,22,25,26,32)/t13-/m0/s1

SMILES: c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)N(Cc1cnc2c(c(nc(=N)[nH]2)O)n1)C=O

10-Formylfolic Acid (L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]formylamino-]benzoyl]-)

CAS: 134-05-4

Other vitamins and their derivatives, nesoi

Formula: C₂₀H₁₉N₇O₇

Color and Shape: Yellow Beige Powder

Molecular weight: 469.1346

Ref: 45-1286300

10-FORMYLFOLIC ACID (25 MG)

CAS: 134-05-4

Formula: C₂₀H₁₉N₇O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.4076

Ref: IN-DA009F1X

10-Formylfolic acid

CAS: 134-05-4

10-Formylfolic acid

Purity: ≥98%

Molecular weight: 469.41g/mol

Ref: 54-BUP01036

Folinic Acid EP Impurity D Disodium Salt

CAS: 134-05-4

Formula: C₂₀H₁₇N₇O₇·2Na

Molecular weight: 467.40 2*22.99

Ref: 4Z-F-068005

10-Formyl Folic Acid

CAS: 134-05-4

Stability Light Sensitive
Applications 10-Formyl Folic Acid is a Folic Acid (CAT# F680300) derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies.
References Keszei, A.P. et al.: Cancer Epidimiol. Biomarker Prev., 18, 1785 (2009); Koning, E.J. et al.: Cancer, 95, 1421 (2002); Baggott, J. E., et al.: J. Nutr., 129, 1315 (1999)

Formula: C₂₀H₁₉N₇O₇

Purity: >90%

Color and Shape: Orange To Dark Brown

Molecular weight: 469.41

Ref: TR-F700450

10-Formyl folic acid

CAS: 134-05-4

10-Formyl folic acid is a type of folic acid that is found in the human serum. It can be detected by liquid chromatography-mass spectrometry (LC-MS/MS). 10-Formyl folic acid has been studied for its potential to be used as an early indicator of leukemia, and can also be used to study the effects of matrix effects on chromatographic methods. 10-Formyl folic acid is often used in product research because it has high detection and can be used to detect streptococcus faecalis.

Formula: C₂₀H₁₉N₇O₇

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 469.41 g/mol

Ref: 3D-FF23551

10-Formyl Folic Acid-13C5 (>90%)

Controlled Product

CAS: 134-05-4

Formula: C₅C₁₅H₁₉N₇O₇

Purity: >90%

Color and Shape: Neat

Molecular weight: 474.371

Ref: TR-F700451

Folinic Acid Impurity D

CAS: 134-05-4

Formula: C₂₀H₁₉N₇O₇

Molecular weight: 469.41

Ref: ST-EA-CP-F34004

Calcium Folinate EP Impurity D

CAS: 134-05-4

Formula: C₂₀H₁₉N₇O₇

Molecular weight: 469.41

Ref: ST-EA-CP-C509004

10-Formylfolic acid

CAS: 134-05-4

10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.

Formula: C₂₀H₁₉N₇O₇

Purity: 98.42%

Color and Shape: Solid

Molecular weight: 469.41

Ref: TM-T24962