CymitQuimica logo

CAS 134-46-3

:

Fluorodeoxyuridylate

Description:
Fluorodeoxyuridylate, also known as 5-fluoro-2'-deoxyuridine monophosphate (FdUMP), is a nucleotide analog that plays a significant role in cancer chemotherapy, particularly in the treatment of colorectal cancer. It is a derivative of deoxyuridine, where a fluorine atom replaces a hydrogen atom at the 5-position of the uracil ring. This modification enhances its ability to inhibit thymidylate synthase, an enzyme critical for DNA synthesis and repair, thereby disrupting the proliferation of cancer cells. FdUMP is typically used in combination with other chemotherapeutic agents, such as leucovorin, to enhance its efficacy. The compound is characterized by its ability to form stable complexes with thymidylate synthase, leading to a prolonged inhibition of the enzyme's activity. In terms of solubility, FdUMP is generally soluble in water, which facilitates its administration in clinical settings. Its pharmacological properties and mechanism of action make it a valuable tool in targeted cancer therapies, although its use must be carefully managed due to potential side effects associated with chemotherapy.
Formula:C9H12FN2O8P
InChI:InChI=1/C9H11FN2O5.H3O4P/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7;1-5(2,3)4/h2,5-7,13-14H,1,3H2,(H,11,15,16);(H3,1,2,3,4)/t5-,6+,7+;/m0./s1
InChI key:InChIKey=HFEKDTCAMMOLQP-RRKCRQDMSA-N
SMILES:O=C1N([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)C2)C=C(F)C(=O)N1
Synonyms:
  • 2'-Deoxy-5-Fluorouridine 5'-(Dihydrogen Phosphate)
  • 2′-Deoxy-5-fluoro-5′-uridylic acid
  • 5'-Uridylic acid, 2'-deoxy-5-fluoro-
  • 5-Fluoro-2′-deoxy-UMP
  • 5-Fluoro-2′-deoxyuridine 5′-monophosphate
  • 5-Fluoro-2′-deoxyuridine 5′-phosphate
  • 5-Fluoro-2′-deoxyuridylate
  • 5-Fluoro-2′-deoxyuridylic acid
  • 5-Fluoro-dUMP
  • 5-Fluorodeoxyuridine 5′-monophosphate
  • See more synonyms
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 1 products.