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CAS 134-90-7

:

(+)-Chloramphenicol

Description:
(+)-Chloramphenicol, with the CAS number 134-90-7, is a broad-spectrum antibiotic originally derived from the bacterium Streptomyces venezuelae. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, making it effective against a variety of Gram-positive and Gram-negative bacteria. This compound is a white to pale yellow crystalline powder, soluble in water and alcohol, and has a relatively low molecular weight. Its chemical structure features a nitro group and a phenolic hydroxyl group, contributing to its antibacterial properties. While it has been widely used in the treatment of infections, its use has declined due to potential side effects, including aplastic anemia and gray baby syndrome in newborns. As a result, it is now primarily reserved for specific cases where other antibiotics are ineffective. Additionally, (+)-Chloramphenicol is notable for its stereochemistry, with the (+) designation indicating its specific optical activity.
Formula:C11H12Cl2N2O5
InChI:InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m0/s1
InChI key:InChIKey=WIIZWVCIJKGZOK-IUCAKERBSA-N
SMILES:[C@H]([C@@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1
Synonyms:
  • (+)-Chloramphenicol
  • (1S,2S)-2-(2,2-Dichloroacetamido)-1-(4-nitrophenyl)-1,3-propanediol
  • 2,2-Dichloro-N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
  • 2,2-dichloro-N-[(1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
  • 2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
  • <span class="text-smallcaps">L</span>-(+)-threo-Chloramphenicol
  • <span class="text-smallcaps">L</span>-threo-(1S,2S)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol
  • <span class="text-smallcaps">L</span>-threo-Chloroamphenicol
  • <span class="text-smallcaps">L</span>-threo-N-Dichloracetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
  • <span class="text-smallcaps">L</span>-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
  • See more synonyms
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Found 3 products.
  • (+)-Chloramphenicol
    Indagoo
    + Info

    (+)-Chloramphenicol

    CAS:
    Formula:C11H12Cl2N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:323.1294

    Ref: IN-DA009FJQ

    1g
    51.00€
    5g
    123.00€
    10g
    185.00€
    50g
    564.00€
  • Dextramycine
    Targetmol
    + Info

    Dextramycine

    CAS:
    Dextramycine is an optic isomer of chloramphenicol.
    Formula:C11H12Cl2N2O5
    Color and Shape:Needles Or Elongated Plates From Water Or Ethylene Dichloride Solid
    Molecular weight:323.13

    Ref: TM-T23985

  • L-(+)-threo-Chloramphenicol
    TRC
    + Info

    L-(+)-threo-Chloramphenicol

    Controlled Product
    CAS:
    <p>Applications The S,S-stereoisomer of Chloramphenicol (C325030). Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.<br>References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),<br></p>
    Formula:C11H12Cl2N2O5
    Color and Shape:Neat
    Molecular weight:323.13

    Ref: TR-C325025

    1g
    1,915.00€
    100mg
    292.00€