CAS 134031-86-0

5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine

Description:

The chemical substance known as "5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine," with the CAS number 134031-86-0, is a modified nucleoside derivative of thymidine. This compound features a phosphoramidate linkage, which enhances its stability and bioavailability, making it of interest in nucleic acid chemistry and therapeutic applications. The presence of the 4,4'-dimethoxytrityl group at the 3' position serves as a protective moiety, facilitating the synthesis of oligonucleotides. The 5' position is modified with a diisopropylamino group and a cyanoethoxy moiety, which can influence the compound's solubility and reactivity. Such modifications are often employed to improve the pharmacokinetic properties of nucleosides, potentially enhancing their efficacy in gene therapy or as antiviral agents. Overall, this compound exemplifies the intricate design of nucleoside analogs for advanced applications in molecular biology and medicinal chemistry.

Formula: C₄₀H₄₉N₄O₉P

Synonyms:

• 2'-OMe-U Phosphoramidite
• 3'-O-(4,4'-Dimethoxytrityl)-thymidine-5'-cyanoethyl Phosphoramidite
• Rev T-5’-amidite
• 3'-O-DMT-thymidine 5'-CE phosphoramidite
• 3’-O-DMTr-thymidine 5’-CE phosphoramidite
• 3'-Dimethoxytrityl-2'-deoxyThymidine,5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
• 5'-O-[(DiisopropylaMino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-diMethoxytrityl)thyMidine, 97%
• 2'-OMe-rU-CE Phosphoramidite
• Thymidine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• DMT-dT-5'-CE Reverse Phosphoramidite
• 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite
• 3'-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-OMe-U Phosphoramidite

CAS: 134031-86-0

Formula: C₄₀H₄₉N₄O₈P

Purity: 97%

Color and Shape: Solid

Molecular weight: 744.8128

Ref: IN-DA007MKY

3'-O-DMTr-thymidine 5'-CE phosphoramidite

CAS: 134031-86-0

3'-O-DMTr-thymidine 5'-CE phosphoramidite

Purity: ≥98%

Molecular weight: 744.81g/mol

Ref: 54-BUP20933

3'-O-DMTr-thymidine 5'-CE phosphoramidite

CAS: 134031-86-0

3'-O-DMTr-thymidine 5'-CE phosphoramidite (2'-OMe-U Phosphoramidite) is a purine nucleoside analog and phosphoramidite derivative .

Formula: C₄₀H₄₉N₄O₈P

Purity: 99.42%

Color and Shape: Solid

Molecular weight: 744.81

Ref: TM-TNU1606

3'-O-DMT-thymidine 5'-CE phosphoramidite

CAS: 134031-86-0

3'-O-DMT-thymidine 5'-CE phosphoramidite is a novel, ribonucleoside phosphoramidites for DNA synthesis and antiviral treatment. It is a modified nucleoside that can be incorporated into DNA during the synthesis process. 3'-O-DMT-thymidine 5'-CE phosphoramidite has shown strong anticancer effects in animal models and has been shown to inhibit replication of herpes simplex virus type 1 in cultured cells. This product is manufactured by chemical synthesis, purified by high performance liquid chromatography (HPLC) and is available as a white powder or crystalline solid.

Formula: C₄₀H₄₉N₄O₈P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 744.83 g/mol

Ref: 3D-PD09188