CAS 134036-52-5

AG 490

Description:

AG 490, with the CAS number 134036-52-5, is a chemical compound known primarily as a selective inhibitor of the Janus kinase (JAK) signaling pathway. It is often utilized in research to study the role of JAK in various biological processes, including cell proliferation, differentiation, and immune responses. AG 490 is characterized by its ability to inhibit the phosphorylation of signal transducer and activator of transcription (STAT) proteins, which are crucial for mediating the effects of cytokines and growth factors. This compound is typically used in cellular and molecular biology studies, particularly in the context of cancer research and inflammatory diseases. AG 490 is usually administered in vitro, and its effects can vary depending on the cell type and experimental conditions. As with many chemical substances, safety precautions should be observed when handling AG 490, as it may pose health risks if not managed properly.

Formula: C₁₇H₁₄N₂O₃

Synonyms:

• (E)-2-Cyano-3-(3,4-Dihydrophenyl)-N-(Phenylmethyl)-2-Propenamide
• A-Cyano-(3,4-Dihydroxy)-N-Benzylcinnamamide
• A-Cyano-(3,4-Dihydroxy)-N-Benzylcinnamide
• 2-Cyano-3-[3,4-Dihydroxyphenyl]-N-[Phenylmethyl]-2-Propenamide
• N-Benzyl-3,4-Dihydroxy-Alpha-Cyanocinnamide
• Ag490
• Tyrphostin AG-490
• Tyrphostin B42
• (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
• AG-490
• TYRPHOSTIN AG 490, 99+%
• TYROPHOSTIN AG490
• 2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide
• N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide
• ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE

Tyrphostin AG 698

CAS: 134036-52-5

Formula: C₁₇H₁₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 294.3047

Ref: IN-DA0070YB

Tyrphostin AG 490

CAS: 134036-52-5

Tyrphostin AG 490

Purity: >99%

Color and Shape: Solid

Molecular weight: 294.30g/mol

Ref: 54-BIT1100

AG-490

CAS: 134036-52-5

AG-490

Purity: 98%

Molecular weight: 294.30g/mol

Ref: 54-OR2500

AG-490

Controlled Product

CAS: 134036-52-5

Applications A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stock, J., et al.: J. Biol. Chem., 267, 19753 (1992), Levitzki, A., et al.: Science, 267, 1782 (1995), Meydan., N., et al.: Nature, 379, 645 (1996), Lu, H., et al.: Drug Metab. Dispos., 31, 572 (2003),

Formula: C₁₇H₁₄N₂O₃

Color and Shape: Neat

Molecular weight: 294.30

Ref: TR-A425000

AG 490

CAS: 134036-52-5

A tyrosine kinase inhibitor with potent activity against EGFR, STAT3, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK. Suppresses IL-2 signaling pathway, inhibits T-cell growth and activation of JAK3, AP-1, STAT, MAPK. Has anti-proliferative and anti-invasive effect on cancer cells.

Formula: C₁₇H₁₄N₂O₃

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 294.3 g/mol

Ref: 3D-FC17241

(E/Z)-AG490

CAS: 134036-52-5

(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.

Formula: C₁₇H₁₄N₂O₃

Color and Shape: Solid

Molecular weight: 294.3

Ref: TM-T60624