CAS 134143-28-5

Glaspimod

Description:

Glaspimod, with the CAS number 134143-28-5, is a synthetic compound primarily investigated for its potential therapeutic applications, particularly in the treatment of autoimmune diseases and inflammatory conditions. It functions as a selective modulator of the sphingosine-1-phosphate (S1P) receptor, which plays a crucial role in regulating immune cell trafficking and inflammation. The compound exhibits properties that may help in reducing the migration of lymphocytes from lymphoid tissues to the bloodstream, thereby potentially mitigating excessive immune responses. Glaspimod has been studied for its pharmacokinetic profile, demonstrating favorable absorption and distribution characteristics. Its safety and efficacy have been evaluated in clinical trials, showing promise in managing conditions such as multiple sclerosis and other related disorders. As with many investigational drugs, ongoing research is essential to fully understand its mechanism of action, therapeutic potential, and any associated side effects. Overall, Glaspimod represents a significant area of interest in the field of immunology and pharmacotherapy.

Formula: C₄₈H₇₄N₁₂O₂₂

InChI: InChI=1/C48H74N12O22/c49-19-5-3-9-29(47(79)80)57-39(71)23(53-45(77)31(21-37(67)68)59-43(75)27(13-17-35(63)64)55-41(73)25-11-15-33(61)51-25)7-1-2-8-24(40(72)58-30(48(81)82)10-4-6-20-50)54-46(78)32(22-38(69)70)60-44(76)28(14-18-36(65)66)56-42(74)26-12-16-34(62)52-26/h23-32H,1-22,49-50H2,(H,51,61)(H,52,62)(H,53,77)(H,54,78)(H,55,73)(H,56,74)(H,57,71)(H,58,72)(H,59,75)(H,60,76)(H,63,64)(H,65,66)(H,67,68)(H,69,70)(H,79,80)(H,81,82)/t23-,24-,25-,26-,27-,28-,29-,30-,31-,32-/m0/s1

Synonyms:

• SK&F 107647
• L-Lysine, 5-oxo-L-prolyl-L-alpha-glutamyl-L-alpha-aspartyl-N8-(5-amino-1-carboxypentyl)-8-oxo-N7-(N-(N-(5-oxo-L-prolyl)-L-alpha-glutamyl)-L-alpha-aspartyl)-2,7,8-triaminooctanoyl-, (S)-
• SK&F-107647
• Glaspimod [INN:BAN]
• (S)-5-Oxo-L-prolyl-L-alpha-glutamyl-L-alpha-aspartyl-N8-(5-amino-1-carboxypentyl)-8-oxo-N7-(N-(N-(5-oxo-L-prolyl)-L-alpha-glutamyl)-L-alpha-aspartyl)-2,7,8-triaminooctanoyl-L-lysine
• (4S,7S,10S,15S,18S,21S)-10,15-bis{[(1S)-5-amino-1-carboxypentyl]carbamoyl}-7,18-bis(carboxymethyl)-5,8,17,20-tetraoxo-4,21-bis({[(2S)-5-oxopyrrolidin-2-yl]carbonyl}amino)-6,9,16,19-tetraazatetracosane-1,24-dioic acid (non-preferred name)
• N(sup 2),N(sup 2)'-((2S,7S)-2,7-Bis((2S)-3-carboxy-2-((2S)-4-carboxy-2-((2S)-5-oxo-2-pyrrolidinecarboxamido)butyramido)propionamido)octanedioyl)di-L-lysine

Glaspimod

CAS: 134143-28-5

Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines.

Formula: C₄₈H₇₄N₁₂O₂₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1171.17

Ref: TM-T25453