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CAS 134150-51-9

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N(alpha)-fmoc-O-[bis(benzyloxy)phos-phoryl]-L-tyrosine

Description:
N(alpha)-fmoc-O-[bis(benzyloxy)phosphoryl]-L-tyrosine is a phosphotyrosine derivative commonly used in peptide synthesis and biochemical research. This compound features a phenylmethoxy (benzyloxy) group, which enhances its stability and solubility, making it suitable for various applications in organic synthesis and biochemistry. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for selective deprotection during peptide synthesis, facilitating the incorporation of phosphorylated tyrosine residues into peptides. The presence of the bis(benzyloxy)phosphoryl moiety indicates that it contains two benzyloxy groups attached to a phosphate, which can influence the compound's reactivity and interaction with biological systems. This compound is typically utilized in studies involving signal transduction pathways, protein interactions, and the development of phosphopeptide-based therapeutics. Its unique structure and functional groups make it a valuable tool for researchers exploring the role of phosphorylation in cellular processes.
Formula:C38H34NO8P
InChI:InChI=1/C38H34NO8P/c40-37(41)36(39-38(42)44-26-35-33-17-9-7-15-31(33)32-16-8-10-18-34(32)35)23-27-19-21-30(22-20-27)47-48(43,45-24-28-11-3-1-4-12-28)46-25-29-13-5-2-6-14-29/h1-22,35-36H,23-26H2,(H,39,42)(H,40,41)/t36-/m0/s1
SMILES:c1ccc(cc1)COP(=O)(OCc1ccccc1)Oc1ccc(cc1)C[C@@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • Fmoc-Tyr(PO3Bzl2)-OH
  • (2S)-3-(4-dibenzyloxyphosphoryloxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
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