CAS 134208-17-6

Mazapertine

Description:

Mazapertine is a chemical compound classified as an atypical antipsychotic, primarily used in the treatment of schizophrenia and other psychiatric disorders. It functions as a dopamine D2 receptor antagonist, which helps to modulate neurotransmitter activity in the brain, thereby alleviating symptoms associated with psychotic disorders. In addition to its action on dopamine receptors, mazapertine also exhibits affinity for serotonin receptors, contributing to its therapeutic effects and side effect profile. The compound is characterized by its relatively low sedative properties compared to other antipsychotics, making it a preferred option for some patients. Its pharmacokinetics involve oral administration, with metabolism primarily occurring in the liver. As with many antipsychotic medications, potential side effects may include weight gain, metabolic changes, and extrapyramidal symptoms, although these may vary among individuals. Overall, mazapertine represents a significant option in the pharmacological management of schizophrenia, with ongoing research into its efficacy and safety profile.

Formula: C₂₆H₃₅N₃O₂

InChI: InChI=1S/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3

InChI key: InChIKey=ZKZFPRUSWCYSGT-UHFFFAOYSA-N

SMILES: O(C(C)C)C1=C(C=CC=C1)N2CCN(CC3=CC(C(=O)N4CCCCC4)=CC=C3)CC2

Synonyms:

• Methanone, [3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]phenyl]-1-piperidinyl-
• [3-[[4-[2-(1-Methylethoxy)phenyl]-1-piperazinyl]methyl]phenyl]-1-piperidinylmethanone
• Piperidine, 1-[3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]benzoyl]-
• Mazapertine