CAS 1342290-43-0: AMG 181

Description: AMG 181, with the CAS number 1342290-43-0, is a small molecule that functions as a selective antagonist of the chemokine receptor CCR9. This compound has garnered attention in the field of immunology and pharmacology, particularly for its potential therapeutic applications in treating autoimmune diseases, such as ulcerative colitis and Crohn's disease. AMG 181 works by inhibiting the migration of T cells to inflamed tissues, thereby modulating the immune response. The substance is characterized by its high specificity for CCR9, which minimizes off-target effects and enhances its safety profile. In terms of its chemical structure, AMG 181 features a unique arrangement of functional groups that contribute to its binding affinity and efficacy. Preclinical studies have indicated promising results regarding its pharmacokinetics and bioavailability, making it a candidate for further clinical development. As research continues, AMG 181 may play a significant role in advancing treatment options for chronic inflammatory conditions.

Formula: Unspecified

Synonyms:

• Arbilumab
• AMG 181
• Immunoglobulin G, anti-(human integrin α4β7) (human monoclonal heavy chain), disulfide with human monoclonal light chain, dimer
• MEDI 7183
• Abrilumab

Abrilumab

CAS: 1342290-43-0

Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.

• Color and Shape: Liquid

Abrilumab

CAS: 1342290-43-0

Anti-Human α4β7 Monoclonal Antibody