CAS 134332-50-6

Galanthamine-N-oxide

Description:

Galanthamine-N-oxide is a chemical compound derived from galanthamine, which is an alkaloid primarily extracted from plants of the Amaryllidaceae family. This substance is characterized by its structural modification, where an N-oxide functional group is introduced, enhancing its pharmacological properties. Galanthamine-N-oxide exhibits potential as a reversible inhibitor of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine, thereby increasing its availability in the synaptic cleft. This mechanism suggests potential applications in treating neurodegenerative diseases, such as Alzheimer's disease. The compound is typically a white to off-white solid and is soluble in polar solvents. Its stability and reactivity can be influenced by environmental factors such as pH and temperature. Additionally, research into its pharmacokinetics and toxicity profiles is ongoing, as understanding these characteristics is crucial for its therapeutic use. Overall, Galanthamine-N-oxide represents a significant area of interest in medicinal chemistry due to its neuroprotective effects and potential therapeutic applications.

Formula: C₁₇H₂₁NO₄

InChI: InChI=1/C17H21NO4/c1-18(20)8-7-17-6-5-12(19)9-14(17)22-16-13(21-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-,18?/m0/s1

SMILES: CN1(=O)CC[C@@]23C=C[C@@H](C[C@@H]2Oc2c(ccc(C1)c32)OC)O

Synonyms:

• (4aS,6R,8aS,11R)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol 11-Oxide
• Galanthamine 10-Oxide
• (4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol 11-oxide

Galanthamine N-Oxide

CAS: 134332-50-6

Galanthamine N-Oxide

Purity: ≥98%

Molecular weight: 303.35g/mol

Ref: 54-BUP00422

Galanthamine N-Oxide

CAS: 134332-50-6

Formula: C₁₇H₂₁NO₄

Molecular weight: 303.36

Ref: 7W-GY6935

Galanthamine N-Oxide

CAS: 134332-50-6

Formula: C₁₇H₂₁NO₄

Purity: 95%~99%

Molecular weight: 303.358

Ref: BP-BP4425

Galanthamine N-Oxide

CAS: 134332-50-6

Galanthamine N-Oxide: EC50 26.2 μM for eel AChE inhibition; blocks active sites in Tc/hAChE/hBChE; derived from Zephyranthes concolor bulbs.

Formula: C₁₇H₂₁NO₄

Purity: 99.29%

Color and Shape: Solid

Molecular weight: 303.35

Ref: TM-T11351

Galanthamine N-Oxide

Controlled Product

CAS: 134332-50-6

Stability Hygroscopic
Applications A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991), Mannens, G., et al.: Drug Metab. Dispos., 30, 553 (2002), Zhao, Q., et al.: J. Clin. Pharmacol., 42, 428 (2002), Geerts, H., et al.: Brain Res., 1033, 186 (2005),

Formula: C₁₇H₂₁NO₄

Color and Shape: Neat

Molecular weight: 303.35

Ref: TR-G188525

Galanthamine N-oxide

Controlled Product

CAS: 134332-50-6

Metabolite of galanthamine

Formula: C₁₇H₂₁NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 303.35 g/mol

Ref: 3D-FG23640

Galanthamine β-N-Oxide

CAS: 134332-50-6

Formula: C₁₇H₂₁NO₄

Molecular weight: 303.36

Ref: ST-EA-CP-G10013