CAS 13435-12-6

Trimethylsilylacetamide

Description:

Trimethylsilylacetamide (TMSA) is an organosilicon compound characterized by the presence of a trimethylsilyl group attached to an acetamide moiety. It is typically a colorless to pale yellow liquid with a distinctive odor. TMSA is known for its utility as a derivatizing agent in analytical chemistry, particularly in gas chromatography and mass spectrometry, where it enhances the volatility and stability of polar compounds. The presence of the trimethylsilyl group increases the hydrophobicity of the molecule, facilitating the analysis of various functional groups. TMSA is also used in organic synthesis and as a reagent in the preparation of silyl derivatives. It is generally stable under standard conditions but should be handled with care due to its potential reactivity with moisture, which can lead to the release of silanol and other byproducts. Safety precautions are advised, as it may cause irritation upon contact with skin or eyes. Overall, Trimethylsilylacetamide is a valuable compound in both research and industrial applications.

Formula: C₅H₁₃NOSi

InChI: InChI=1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7)

InChI key: InChIKey=LWFWUJCJKPUZLV-UHFFFAOYSA-N

SMILES: N([Si](C)(C)C)C(C)=O

Synonyms:

• (Acetylamino)trimethylsilane
• 2-(Trimethylsilyl)Acetamide
• Acetamide, N-(trimethylsilyl)-
• NSC 139859
• Trimethylsilylacetamide
• N-(Trimethylsilyl)acetamide

N-Trimethylsilylacetamide

CAS: 13435-12-6

Formula: C₅H₁₃NOSi

Purity: >98.0%(GC)

Color and Shape: White or Colorless to Light orange to Yellow powder to lump to clear liquid

Molecular weight: 131.25

Ref: 3B-T0590

N-(Trimethylsilyl)acetamide

CAS: 13435-12-6

Formula: C₅H₁₃NOSi

Purity: 95%

Color and Shape: Solid

Molecular weight: 131.2483

Ref: IN-DA003SFS

N-(Trimethylsilyl)Acetamide

CAS: 13435-12-6

N-(Trimethylsilyl)Acetamide

Purity: 95%

Molecular weight: 131.25g/mol

Ref: 54-OR1014045

N-Trimethylsilylacetamide

Controlled Product

CAS: 13435-12-6

Stability Moisture Sensitive
Applications N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).
References Takano, R. et al.: J. Carb. Chem., 14, 885 (1995); Rao, K. et al.: Synth. Comm., 37, 2275 (2007);

Formula: C₅H₁₃NOSi

Color and Shape: Neat

Molecular weight: 131.25

Ref: TR-T796720

N-Trimethylsilylacetamide

CAS: 13435-12-6

S18875 - N-Trimethylsilylacetamide

Formula: C₅H₁₃NOSi

Purity: 95%

Color and Shape: Solid

Molecular weight: 131.25

Ref: 10-S18875