CAS 134418-28-3

Dehydroandrographolide

Description:

Dehydroandrographolide is a natural compound derived from the plant Andrographis paniculata, commonly known for its medicinal properties. It is a bicyclic diterpenoid lactone, characterized by its complex structure that includes multiple rings and functional groups. This compound exhibits a range of biological activities, including anti-inflammatory, antioxidant, and antimicrobial properties, making it of interest in pharmacological research. Dehydroandrographolide has been studied for its potential therapeutic effects in various conditions, including infections and inflammatory diseases. Its mechanism of action often involves modulation of signaling pathways and inhibition of pro-inflammatory cytokines. Additionally, it is known to interact with various biological targets, contributing to its diverse pharmacological effects. The compound is typically analyzed using techniques such as chromatography and spectroscopy to determine its purity and concentration in research settings. Overall, dehydroandrographolide represents a significant area of study in natural product chemistry and drug development, highlighting the importance of plant-derived compounds in modern medicine.

Formula: C₂₀H₂₈O₅

InChI: InChI=1/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16?,17-,19+,20+/m1/s1

InChI key: InChIKey=YIIRVUDGRKEWBV-CZUXAOBFSA-N

SMILES: C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@@H]2C/C=C\3/C(=O)OC=C3)[H]

Synonyms:

• (2R,5R,10R)-2,17-dihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,15-octahydro-20:5,10-dicycloretinal
• (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone
• 14-(P)
• 14-Deoxy-11-dehydroandrographolide
• 2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-
• 2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-
• DEOXY-11,12-DiDehydroandrographolide
• Dehydroanddrographolide
• Dehydroandrographoline
• andrographolide, Dehydro-
• Dehydroandrographolide
• Dehydrographkide
• 2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

CAS: 134418-28-3

Formula: C₂₀H₂₈O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 332.4339

Ref: IN-DA009AGI

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide

Purity: ≥98%

Molecular weight: 332.43g/mol

Ref: 54-BUP06369

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.

Formula: C₂₀H₂₈O₄

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 332.43

Ref: TM-T2738

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. It possesses activity against HBV DNA replication with IC50 values of 22.58 uM and low SI values of 8.7 ; it can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Formula: C₂₀H₂₈O₄

Purity: 95%~99%

Molecular weight: 332.44

Ref: BP-BP0459

Dehydroandrographolide

CAS: 134418-28-3

Formula: C₂₀H₂₈O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 332.43

Ref: 7W-GP8945

Dehydroandrographolide

CAS: 134418-28-3

Lactone

Formula: C₂₀H₂₈O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 332.44

Ref: 5G-89623

Dehydroandrographoline

CAS: 134418-28-3

Dehydroandrographolide is a natural product that has been used in traditional medicine to treat bowel disease, diabetes, and cancer. This compound is found in the plant Andrographis paniculata and has been shown to inhibit P-glycoprotein (P-gp) efflux transporter activity. Dehydroandrographolide also induces autophagy, which is the process by which cells degrade their own components under conditions of nutrient starvation or other stress. In addition, dehydroandrographolide succinate inhibits potassium channel activity and may be a potential anticancer agent. The analytical method for dehydroandrographolide succinate is based on an acid hydrolysis followed by high performance liquid chromatography with UV detection at λ max 218 nm.

Formula: C₂₀H₂₈O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 348.43 g/mol

Ref: 3D-FD11384