CAS 134448-10-5

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

Description:

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide, identified by its CAS number 134448-10-5, is a synthetic compound that belongs to the class of epoxides and amides. This substance is characterized by its unique structural features, including an epoxide group, which contributes to its reactivity and potential biological activity. The presence of the isoleucine and proline residues suggests that it may interact with biological systems, potentially influencing protein synthesis or enzyme activity. Its propylamide moiety may enhance lipophilicity, affecting its solubility and permeability in biological membranes. The compound is likely to exhibit specific stereochemical properties due to the presence of chiral centers, which can influence its pharmacological profile. While detailed information on its biological activity may be limited, compounds of this nature are often investigated for their potential therapeutic applications, particularly in the fields of medicinal chemistry and drug design. Safety and handling precautions should be observed, as with any chemical substance, due to the potential for reactivity and biological effects.

Formula: C₁₈H₂₉N₃O₆

InChI: InChI=1/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)

SMILES: CCCN=C(C1C(C(=NC(C(C)CC)C(=O)N2CCCC2C(=O)O)O)O1)O

Synonyms:

• Ca 074
• N-(3-Propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline
• L-Proline, 1-(N-((3-((propylamino)carbonyl)oxiranyl)carbonyl)-L-isoleucyl)-, (2S-trans)-
• N-{[(3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline
• N-{[3-(propylcarbamoyl)oxiran-2-yl]carbonyl}isoleucylproline

N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

CAS: 134448-10-5

Formula: C₁₈H₂₉N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.4394

Ref: IN-DA009ATG

CA-074

CAS: 134448-10-5

Formula: C₁₈H₂₉N₃O₆

Molecular weight: 383.44

Ref: 7W-GK2163

CA 074

CAS: 134448-10-5

CA 074

Purity: ≥95%

Molecular weight: 383.44g/mol

Ref: 54-BUP07234

CA-074

CAS: 134448-10-5

CA-074 is a research tool that can be used to study protein interactions. CA-074 is a small, synthetic peptide and a potent inhibitor of the ion channel TRPC1. It has been shown to inhibit the calcium currents in HEK293 cells expressing TRPC1 channels. CA-074 inhibits the kinase activity of PLCγ2, which leads to reduced phosphoinositide levels and a decrease in cell proliferation. CA-074 also inhibits PKCδ and PKCε, which are members of the protein kinase C family.
The inhibition of these enzymes by CA-074 causes an increase in the intracellular concentration of diacylglycerol (DAG) and inositol triphosphate (IP3). These two molecules are involved in G protein signaling pathways that regulate cell proliferation, differentiation, and survival.

Formula: C₁₈H₂₉N₃O₆

Purity: Min. 95%

Molecular weight: 383.44 g/mol

Ref: 3D-IEC-4322-V

CA 074

CAS: 134448-10-5

CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates

Formula: C₁₈H₂₉N₃O₆

Purity: 97.80%

Color and Shape: Solid

Molecular weight: 383.44

Ref: TM-T21509

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

CAS: 134448-10-5

Inhibitor of cathepsin B

Formula: C₁₈H₂₉N₃O₆

Purity: Min. 95%

Molecular weight: 383.44 g/mol

Ref: 3D-FE111058

L-trans-Epoxysuccinyl-Ile-Pro-OH propylamide

CAS: 134448-10-5

CA074, a potent inhibitor specific for cathepsin B in vitro (IC₅₀= 2.24 nM for rat liver cathepsin B) and in vivo.

Formula: C₁₈H₂₉N₃O₆

Purity: 98.3%

Molecular weight: 383.45

Ref: 01-4026670