CAS 134500-80-4

amyloid B-protein fragment 1-43

Description:

Amyloid beta-protein fragment 1-43, often referred to as Aβ1-43, is a peptide associated with Alzheimer's disease and is derived from the amyloid precursor protein (APP). This fragment consists of 43 amino acids and is known for its role in the formation of amyloid plaques, which are characteristic of Alzheimer's pathology. The peptide is hydrophobic, which contributes to its propensity to aggregate and form fibrils, a process that is believed to be neurotoxic. Aβ1-43 can undergo post-translational modifications, influencing its aggregation behavior and biological activity. The presence of this fragment in the brain is linked to neuroinflammation and synaptic dysfunction, making it a significant target for research into therapeutic interventions for Alzheimer's disease. Its CAS number, 134500-80-4, is used for identification in chemical databases. Understanding the properties and behavior of Aβ1-43 is crucial for developing strategies to mitigate its detrimental effects in neurodegenerative diseases.

Formula: C₂₀₇H₃₁₈N₅₆O₆₂S

Synonyms:

• Amyloid .beta.-Protein (1-43)
• H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr-OH
• Beta-Amyloid (1-43)
• Beta-Amyloid 1-43,human
• Abeta 1-43

Amyloid β-Protein (1-43)

CAS: 134500-80-4

The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer’s disease and Down’s syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.

Formula: C₂₀₇H₃₁₈N₅₆O₆₂S

Purity: 92.7%

Color and Shape: White Lyophilisate

Molecular weight: 4615.21

Ref: 01-4018358

Amyloid Beta-Protein (Human, 1-43)

CAS: 134500-80-4

Amyloid beta (Aβ) is a peptide that is associated with the development of Alzheimer's disease. It is used as a research tool in cell biology, pharmacology and neuroscience. Amyloid beta-protein has been shown to activate certain receptors on the surface of cells, including ion channels. This protein also binds to antibodies that are specific for Aβ and can be used in immunohistochemistry experiments.

Formula: C₂₀₇H₃₁₈N₅₆O₆₂S

Purity: Min. 95%

Molecular weight: 4,615.1 g/mol

Ref: 3D-PAB-4370-V

Amyloid beta-Protein (1-43)

CAS: 134500-80-4

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Formula: C₂₀₇H₃₁₈N₅₆O₆₂S

Purity: Min. 95%

Molecular weight: 4,615.15 g/mol

Ref: 3D-FA108473