CAS 134517-34-3

2-[(2-Chloro-4-quinazolinyl)amino]ethanol

Description:

2-[(2-Chloro-4-quinazolinyl)amino]ethanol, with the CAS number 134517-34-3, is a chemical compound characterized by its unique structure that includes a quinazoline moiety and an amino alcohol functional group. This compound typically appears as a solid or crystalline substance and is soluble in polar solvents due to the presence of the hydroxyl (-OH) group. The chloro substituent on the quinazoline ring contributes to its reactivity and potential biological activity. Compounds of this nature are often studied for their pharmacological properties, particularly in the context of medicinal chemistry, where they may exhibit activity against various biological targets. The presence of both the amino and hydroxyl groups suggests potential for hydrogen bonding, influencing its interactions in biological systems. Additionally, the compound's stability and reactivity can be affected by environmental conditions such as pH and temperature, making it of interest in both synthetic and applied chemistry contexts.

Formula: C₁₀H₁₀ClN₃O

InChI: InChI=1S/C10H10ClN3O/c11-10-13-8-4-2-1-3-7(8)9(14-10)12-5-6-15/h1-4,15H,5-6H2,(H,12,13,14)

InChI key: InChIKey=VZTMYLWJKCAXMZ-UHFFFAOYSA-N

SMILES: N(CCO)C=1C2=C(N=C(Cl)N1)C=CC=C2

Synonyms:

• Ethanol, 2-[(2-chloro-4-quinazolinyl)amino]-
• 2-[(2-Chloro-4-quinazolinyl)amino]ethanol
• 2-[(2-Chloroquinazolin-4-yl)amino]ethan-1-ol

2-[(2-Chloroquinazolin-4-yl)amino]ethan-1-ol

CAS: 134517-34-3

2-[(2-Chloroquinazolin-4-yl)amino]ethan-1-ol (CQAEE) is a prodrug that is enzymatically hydrolyzed in vivo to the active form CQAE. It is an inhibitor of carbonic anhydrase enzymes and has been shown to be more potent than amiodarone and less toxic than acetazolamide. CQAEE has been shown to be effective in vitro against human erythrocytes, homopolymers, and amiodarone, but not in vivo against congestive heart failure. The process of hydrolysis by enzymes causes the release of a carboxylic acid and ethylene glycol which are responsible for the observed therapeutic effects. The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is an antituberculosis drug that belongs to the class of rifamycins

Formula: C₁₀H₁₀ClN₃O

Purity: Min. 95%

Molecular weight: 223.66 g/mol

Ref: 3D-JFA51734