CAS 134523-01-6

Atorvastatin sodium

Description:

Atorvastatin sodium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular diseases. It functions as an HMG-CoA reductase inhibitor, effectively decreasing cholesterol synthesis in the liver. The substance appears as a white to off-white powder and is soluble in water, making it suitable for oral formulations. Atorvastatin sodium is characterized by its ability to lower low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol levels. Its pharmacokinetics involve extensive hepatic metabolism, primarily via cytochrome P450 3A4, leading to a significant first-pass effect. The drug is typically administered in tablet form, with dosage adjusted based on individual patient needs and response. Common side effects may include muscle pain, gastrointestinal disturbances, and potential liver enzyme elevation, necessitating regular monitoring during treatment. Overall, atorvastatin sodium is a crucial therapeutic agent in the management of dyslipidemia and cardiovascular risk reduction.

Formula: C₃₃H₃₅FN₂O₅·Na

InChI: InChI=1S/C33H35FN2O5.Na/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/t26-,27-;/m1./s1

InChI key: InChIKey=PMXVEIDZHIBOFG-CNZCJKERSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Na]

Synonyms:

• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, monosodium salt, (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, monosodium salt, [R-(R*,R*)]-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, sodium salt (1:1), (βR,δR)-
• Atorvastatin sodium salt
• [R-(R',R')]-2-(4-Fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-5-(1-methylethyl)-1-H-pyrrol-1-(-dihydrogen)heptanoic acid sodium
• sodium (3R,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-4,5-dihydropyrrol-1-yl]-3,5-dihydroxy-heptanoate
• Atorvastatin sodium

Atorvastatin Sodium

CAS: 134523-01-6

Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on

Formula: C₃₃H₃₄FN₂NaO₅

Purity: 99.88% - >99.99%

Color and Shape: Solid

Molecular weight: 580.63

Ref: TM-T20887

Atorvastatin sodium salt - Bio-X ™

CAS: 134523-01-6

Atorvastatin is an HMG-CoA reductase inhibitor which is used to lower lipid levels and to reduce the risk of cardiovascular disease. This drug belongs to the class of medicines called statins. It lowers abnormal levels of cholesterol and lipids to reduce the risk of cardiovascular disease by inhibiting the enzyme HMG-CoA.

Formula: C₃₃H₃₅FN₂O₅•Na

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 581.63 g/mol

Ref: 3D-BA164224

(3R,5R)-Atorvastatin Sodium Salt

Controlled Product

CAS: 134523-01-6

Applications (3R,5R)-Atorvastatin Sodium Salt is an Atorvastatin impurity in bulk drug and tablets.
References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),

Formula: C₃₃H₃₄FN₂O₅·Na

Color and Shape: Neat

Molecular weight: 580.622

Ref: TR-A791730

Atorvastatin sodium

CAS: 134523-01-6

HMG-CoA reductase antagonist

Formula: C₃₃H₃₅FN₂O₅•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 581.63 g/mol

Ref: 3D-FA64947