CAS 134566-79-3

Ethambutol Hydrochloride

Description:

Ethambutol hydrochloride is an antitubercular medication primarily used in the treatment of tuberculosis. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range that is typically neutral to slightly acidic. The compound functions by inhibiting the synthesis of the mycobacterial cell wall, thereby preventing the growth of Mycobacterium tuberculosis. Ethambutol is characterized by its ability to selectively target bacterial cells, making it effective in combination therapy for tuberculosis to reduce the risk of resistance. The substance is generally well-tolerated, though it can cause side effects such as optic neuritis, which necessitates monitoring of visual acuity during treatment. Ethambutol hydrochloride is administered orally and is often part of a multi-drug regimen, highlighting its importance in public health strategies against tuberculosis. Its chemical structure includes a butanol moiety, which contributes to its pharmacological properties. Overall, Ethambutol hydrochloride plays a crucial role in the management of tuberculosis, particularly in cases where other treatments may not be effective.

Synonyms:

• 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, [R-(R*,R*)]-

Ethambutol Related Compound B (((2R,2'R)-2,2'-[Ethane-1,2-diylbis(azanediyl)]dibutan-1-ol) dihydrochloride)

CAS: 134566-79-3

Amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters, salts therof, nesoi

Formula: C₁₀H₂₄N₂O₂·2HCl

Color and Shape: White Solid

Molecular weight: 204.18378

Ref: 45-1257029

Ethambutol EP Impurity C DiHCl (2R,2'R-Ethambutol DiHCl)

CAS: 134566-79-3

Formula: C₁₀H₂₄N₂O₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 204.31 2*36.46

Ref: 4Z-E-275

(R,R)-Ethambutol-d4 DiHCl

CAS: 134566-79-3

Formula: C₁₀H₂₀D₄N₂O₂·2HCl

Molecular weight: 208.34 2 36.46

Ref: 4Z-E-277

(R,R)-Ethambutol-d4 Dihydrochloride

Controlled Product

CAS: 134566-79-3

Stability Hygroscopic
Applications (R,R)-Ethambutol-d4 Dihydrochloride is the isotope labelled analog of (R,R)-Ethambutol Dihydrochloride (E889805); a compound that shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800) which is an antibacterial (tuberculostatic).
References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962); Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971); Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)

Formula: C₁₀H₂₂D₄Cl₂N₂O₂

Color and Shape: White To Off-White

Molecular weight: 281.26

Ref: TR-E889807

(R,R)-Ethambutol Dihydrochloride

Controlled Product

CAS: 134566-79-3

Applications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).
References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)

Formula: C₁₀H₂₆Cl₂N₂O₂

Color and Shape: Neat

Molecular weight: 277.23

Ref: TR-E889805