CAS 134580-64-6

.alpha.2.beta.1 Integrin Recognition Sequence

Description:

The substance known as the ".alpha.2.beta.1 Integrin Recognition Sequence" with the CAS number 134580-64-6 is a peptide that plays a crucial role in cell adhesion and signaling processes. This sequence is recognized by the integrin receptors, specifically the alpha-2 beta-1 integrin, which is involved in various biological functions, including cell migration, tissue repair, and immune responses. The peptide typically consists of a specific arrangement of amino acids that facilitates binding to the integrin, promoting interactions between cells and the extracellular matrix. Its characteristics include being water-soluble and having a relatively low molecular weight, which allows for easy diffusion in biological systems. The sequence is often utilized in research and therapeutic applications, particularly in studies related to cancer metastasis, wound healing, and tissue engineering. Understanding its structure and function is essential for developing targeted therapies that can modulate integrin activity in various diseases.

Formula: C₁₄H₂₂N₄O

Synonyms:

• H-Asp-Gly-Glu-Ala-OH

DGEA

CAS: 134580-64-6

Formula: C₁₄H₂₂N₄O₉

Molecular weight: 390.35

Ref: 7W-GK0400

α2β1 Integrin Ligand Peptide

CAS: 134580-64-6

The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular

Formula: C₁₄H₂₂N₄O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.35

Ref: TM-TP1484

a2b1Integrin Recognition Sequence

CAS: 134580-64-6

a2b1Integrin Recognition Sequence is a chemotherapeutic drug that is used in experimental models of hyperproliferative diseases, such as cancer. It activates α subunit of integrins, which are expressed on cells and mediate the adhesion to extracellular matrix proteins. The drug binds to integrin receptors on the surface of tubule cells and promotes their death by apoptosis. This protein stabilizes hydrogen bonding interactions between two or more molecules that are present at a site of chemical reaction, thus inhibiting cellular proliferation and tumor growth. As a result, a2b1Integrin Recognition Sequence inhibits the proliferation of human serum albumin (HSA) and basic fibroblast growth factor (bFGF), which are cell culture models for α subunit-integrin receptor interactions. Analysis of the structure of this protein reveals an integrin recognition sequence motif with three invariant residues: Arg-Gly-Asp (RGD).

Formula: C₁₄H₂₂N₄O₉

Purity: Min. 95%

Molecular weight: 390.35 g/mol

Ref: 3D-FI108428