CAS 13461-01-3

Aceprometazine

Description:

Aceprometazine is a phenothiazine derivative primarily used as an antipsychotic and sedative medication. It exhibits properties such as antihistaminic, antiemetic, and sedative effects, making it useful in various clinical settings, including the management of anxiety and agitation. The compound has a relatively low solubility in water but is soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Aceprometazine acts by blocking dopamine receptors in the central nervous system, contributing to its tranquilizing effects. It is typically administered in oral or injectable forms, and its pharmacokinetics involve hepatic metabolism, with metabolites excreted primarily through urine. Common side effects may include sedation, dizziness, and potential anticholinergic effects. Due to its sedative properties, caution is advised when used in conjunction with other central nervous system depressants. Overall, aceprometazine is a versatile medication with a range of therapeutic applications, though it requires careful monitoring due to its side effect profile.

Formula: C₁₉H₂₂N₂OS

InChI: InChI=1S/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3

InChI key: InChIKey=XLOQNFNTQIRSOX-UHFFFAOYSA-N

SMILES: C(C(N(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(C(C)=O)C2

Synonyms:

• 1-(10-(2-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone
• 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]ethanone
• 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone
• 1664 Cb
• 1664Cb
• Aceprometazin
• Aceprometazina
• Aceprometazina [INN-Spanish]
• Aceprometazine [INN:DCF]
• Aceprometazinum
• Aceprometazinum [INN-Latin]
• Acepromethazine
• Brn 0038528
• Ethanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)- (9CI)
• Ethanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
• Ketone, 10-(2-(dimethylamino)propyl)phenothiazin-2-yl methyl
• Unii-984N9Ytm4Y
• 4-27-00-02910 (Beilstein Handbook Reference)

Acepromethazine-d6

Controlled Product

CAS: 13461-01-3

Formula: C₁₉D₆H₁₆N₂OS

Color and Shape: Neat

Molecular weight: 332.493

Ref: TR-A130912

Acepromethazine

Controlled Product

CAS: 13461-01-3

Applications Acepromethazine is a phenothiazine derivative that is often used in combination with Meprobamate (M227750) for the treatment of sleep disorders.
References Mercier, J., et al.: Arznei-Forschung, 24, 163 (1974)

Formula: C₁₉H₂₂N₂OS

Color and Shape: Dark Yellow To Dark Brown

Molecular weight: 326.46

Ref: TR-A130910

Aceprometazine

CAS: 13461-01-3

Aceprometazine (1664CB) is an antipsychotic which is orally active. Aceprometazine can be used in psychiatric disorders research, for example, depression [1].

Formula: C₁₉H₂₂N₂OS

Color and Shape: Solid

Molecular weight: 326.46

Ref: TM-T60913