CAS 1346598-59-1

DepropylaMino Hydroxy Propafenone-d5

Description:

DepropylaMino Hydroxy Propafenone-d5 is a deuterated derivative of propafenone, a class 1c antiarrhythmic agent used primarily for the treatment of certain types of cardiac arrhythmias. The deuterated form, indicated by the "d5" in its name, suggests that five hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving drug metabolism and pharmacodynamics. The compound retains the core structure of propafenone, which includes a phenylpropylamine moiety, contributing to its biological activity. Its characteristics include a specific molecular weight, solubility in organic solvents, and potential interactions with biological targets, which are essential for its function as an antiarrhythmic agent. Additionally, the presence of deuterium can aid in analytical techniques such as mass spectrometry, allowing for precise tracking of the compound in biological systems.

Formula: C₁₈H₂₀O₄

InChI: InChI=1S/C18H20O4/c19-12-15(20)13-22-18-9-5-4-8-16(18)17(21)11-10-14-6-2-1-3-7-14/h1-9,15,19-20H,10-13H2/i12D2,13D2,15D

InChI key: InChIKey=KRSTZDUMPGTWJG-YZYYPZMPSA-N

SMILES: C(CCC1=CC=CC=C1)(=O)C2=C(OC(C(C(O)([2H])[2H])(O)[2H])([2H])[2H])C=CC=C2

Synonyms:

• DepropylaMino Hydroxy Propafenone-d5
• 1-[2-[2,3-Dihydroxy(propoxy-d5)]phenyl]-3-phenyl-1-propanone
• 1-[2-(1,1,2,3,3-Pentadeuterio-2,3-dihydroxypropoxy)phenyl]-3-phenylpropan-1-one
• Propafenone Impurity 37

Depropylamino Hydroxy Propafenone-d5

Controlled Product

CAS: 1346598-59-1

Applications A labelled metabolite of the sodium channel blocker Propafenone (P757500).
References Hege, H.G. et al.: Arzneim.-Forsch., 34, 972 (1984); Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);

Formula: C₁₈H₁₅D₅O₄

Color and Shape: Neat

Molecular weight: 305.38

Ref: TR-D288637