CAS 1346599-65-2

PhentolaMine-d4 Hydrochloride

Description:

Phentolamine-d4 hydrochloride is a deuterated form of phentolamine, a non-selective alpha-adrenergic antagonist primarily used in the treatment of hypertension and as a vasodilator. The "d4" designation indicates that the compound contains four deuterium atoms, which are isotopes of hydrogen, replacing regular hydrogen atoms in the molecular structure. This modification can enhance the stability and tracking of the compound in various analytical applications, such as pharmacokinetic studies. Phentolamine-d4 hydrochloride retains the pharmacological properties of its non-deuterated counterpart, acting by blocking alpha-adrenergic receptors, which leads to vasodilation and a decrease in blood pressure. The hydrochloride salt form enhances its solubility in water, making it suitable for various formulations. As with other deuterated compounds, it is often used in research settings to study drug metabolism and interactions without interference from the natural abundance of hydrogen isotopes. Safety and handling precautions should be observed, as with any chemical substance, due to potential biological effects and the need for proper laboratory practices.

Formula: C₁₇H₂₀ClN₃O

Synonyms:

• Regitine-d4 Hydrochloride
• [2H4]-Phentolamine Hydrochloride
• 2-[N-(M-Hydroxyphenyl)-p-toluidinoMethyl]iMidazoline-d4 Hydrochloride
• 3-[[(4,5-Dihydro-1H-iMidazol-2-yl)Methyl](4-Methylphenyl)aMino]phenol-d4 Hydrochloride
• 3-[4-methyl-N-[(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)methyl]anilino]phenol:hydrochloride
• Phentolamine-d4 HCl (Regitine-d4 HCl)
• PhentolaMine-d4 Hydrochloride
• DNP-d4

Phentolamine-d4 HCl

CAS: 1346599-65-2

Formula: C₁₇H₁₅D₄N₃O·HCl

Color and Shape: Off-White Solid

Molecular weight: 285.38 36.46

Ref: 4Z-P-189005

Phentolamine-d4 Hydrochloride

Controlled Product

CAS: 1346599-65-2

Applications A labelled Phentolamine (P302550). An adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949), Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970), Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976)

Formula: C₁₇D₄H₁₅N₃O·HCl

Color and Shape: Light Brown Solid

Molecular weight: 321.84

Ref: TR-P302552

Phentolamine-d4 hydrochloride

CAS: 1346599-65-2

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Formula: C₁₇H₂₀ClN₃O

Purity: Min. 95%

Molecular weight: 321.8 g/mol

Ref: 3D-WDC59965